In vitro Activity of Arbutus unedo Aqueous Extract against Leishmania infantum Promastigote
Idir Moualek, Abdelkamel Mouloua, Ghenima Iratni Aiche, Abdenassar Harrar, Nassima Achour, Celia Zerrouki, Ouerdia Mezine, Karim Houali
Annual Research & Review in Biology · pp. 1–5 · Published 27 Apr 2017
10.9734/ARRB/2017/32556Abstract
Considered as a major public health problem, leishmaniasis incidence continues to increase due to lack of vaccine. In addition, drugs routinely used for the treatment of this disease have associated side effects. This justifies a need to develop new drug treatments. It is in this perspective that our study is inscribed. In vitro antileishmanial activity of the aqueous extract of Arbutus unedo leaves was evaluated against promastigotes of L. infantum (MON-1/DZ/01/LIPA1227/01) by in vitro promastigote cell assay. The extract of the studied leaves showed remarkable antileishmanial in vitro activity (74% mortality at 100 µg/ml) against the promastigotes of Leishmania infantum, in a concentration dependent manner.
References (14)
- 1 Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450 [DOI]
- 2 A review of natural products with antileishmanial activity [DOI]
- 3 Abietane diterpenoids and triterpenoic acids from Salvia cilicica and their antileishmanial activities [DOI]
- 4 Arbutus unedo L.: Chemical and Biological Properties [DOI]
- 5 Antioxidant and anti-inflammatory activities of Arbutus unedo aqueous extract [DOI]
- 6 Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants [DOI]
- 7 Mutagenic effect, antioxidant and anticancer activities of six medicinal plants from Burkina Faso [DOI]
- 8 In vitro sensitivity of Leishmania donovani to organometallic derivatives of pentamidine [DOI]
- 9 Synthetic Derivatives of Curcumin and their Activity against Leishmania amazonensis [DOI]
- 10 Epidemiology of Visceral Leishmaniasis in Algeria: An Update [DOI]
- 11 In vitro activity of Arbutus unedo against Leishmania tropica promastigotes.
- 12 Tannins and Related Compounds: Killing of Amastigotes of Leishmania donovani and Release of Nitric Oxide and Tumour Necrosis Factor a in Macrophages in vitro [DOI]
- 13 Iranian Journal of Pharmaceutical Research [DOI]
- 14 Advances in Pharmacological Sciences [DOI]
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