Impact of (ELIOZU) Dumpsite Leachates on Some Haematological Parameters in Wistar Rats

Abstract

Leachates contain deleterious constituents that may cause contamination of ground and surface water leading to serious risks to the ecosystem and human health. The exposure of the environment to dumpsite leachate may occur in different ways, such as uncontrolled overflow, rainfall and infiltration. This study therefore, attempts to determine the possible effects of (Eliozu) dumpsite leachates on some haematological parameters in Wistar rats. 25 Wistar rats weighing between 180g and 250g were divided into five groups of 5 animals each. Groups are as follows: Group 1: received 1ml of commercial bottle water, Group 2: received near-by borehole water, Group 3: received 10% of leachate concentrations, Groups 4 and 5: received 50% and 100% of leachate concentrations every 24 hours for 90 consecutive days. At the end of the gavaging of the leachates, blood samples were collected for heamatological parameters analysis using automated method. Results obtained shows a significant (p<0.001) reduction in some hematological parameters compared with control. Paradoxically, the mean corpuscular volume (MCV), red blood cell distribution width-standard deviation and red blood cell distribution width-coefficient of variation show significant increase (p<0.001) compared with the control. There were also significant decreases in weights of the experimental animals while compared with the control group. Eliozu dumpsite leachates demonstrated some toxicological potentials on Red Blood Cells (RBCs) and RBC indices; White Blood Cells (WBCs) and WBC Differentials in Wistar rats. We recommend further studies in this regard.