Impact of Cervical Nodal Metastases on the Prognosis and Survival of Pyriform Sinus Carcinoma
Rahul Shil, Shreyasee Das, Saikat Das
Journal of Pharmaceutical Research International · pp. 71–77 · Published 31 Oct 2025
10.9734/jpri/2025/v37i117767Abstract
Pyriform sinus carcinoma, a common hypopharyngeal malignancy, often presents late due to the silent progression of symptoms and early submucosal spread. We report the case of a 55-year-old male who presented with progressively enlarging neck swelling for 10 months. Clinical evaluation and imaging revealed a lesion in the right pyriform fossa with multiple cervical lymph node metastases and possible distant spread. Histopathology confirmed a moderately differentiated squamous cell carcinoma. The patient was initiated on systemic chemotherapy with Paclitaxel and Carboplatin, supported by pre medications and palliative care measures. This case highlights the classical late presentation of pyriform sinus carcinoma, diagnostic challenges, and the importance of multimodality treatment. Despite advances in oncology, the prognosis for advanced hypopharyngeal carcinoma remains poor, underscoring the need for early detection and preventive strategies.
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