Immunomodulatory Fungi: An Alternative for the Treatment of Cancer
Diana Lorena Nieto-Mosquera, Hugo Ramiro Segura-Puello, Juan Sebastián Segura-Charry, Diana Milena Muñoz-Forero, Andrea Catalina Villamil-Ballesteros
Journal of Cancer and Tumor International · pp. 1–13 · Published 26 Jul 2019
10.9734/jcti/2019/v9i230106Abstract
The present study aims to determine the role of immunomodulatory fungi for the treatment of cancer as an alternative way. Mushrooms have been part of human culture for thousands of years, many cultures especially from the East, recognized that the extracts of certain fungi could have great health benefits. Recent research has focused on identifying compounds that can modulate, positively or negatively, the biological responses of immune cells. These compounds stimulate immunity, and not only for the treatment of cancer, but also for immunodeficiency diseases; for drug-induced generalized immune suppression; for therapy combined with antibiotics and as adjuvant for vaccines. The medicinal mushrooms are considered as immunomodulators, they are able to regulate the immune system. A diverse collection of bioactive polysaccharides, glycoproteins, glycopeptides, and proteoglycans have an effect on the proliferation and differentiation of immune cells and cytokines. Different purified polysaccharides have had clinical use in Japan, China, and Korea for many years, without reports of negative effects in the short term or in the long term. Different studies have shown that the application of polysaccharide extracts can have a cancer prevention effect and a restriction of tumor metastasis; they have also been used to treat microbial and viral infections, cardiovascular diseases and diabetes.
References (29)
- 1 Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides [DOI]
- 2 Antitumor polysaccharides from mushrooms: a review on their isolation process, structural characteristics and antitumor activity [DOI]
- 3 The effects of β-glucan on human immune and cancer cells [DOI]
- 4 Glucans from fruit bodies of cultivated mushrooms Pleurotus ostreatus and Pleurotus eryngii: Structure and potential prebiotic activity [DOI]
- 5 Antioxidative and immunomodulating activities of polysaccharide extracts of the medicinal mushrooms Agaricus bisporus, Agaricus brasiliensis, Ganoderma lucidum and Phellinus linteus [DOI]
- 6 Mushroom immunomodulators: unique molecules with unlimited applications [DOI]
- 7 Therapeutic intervention with complement and β-glucan in cancer [DOI]
- 8 Medicinal mushrooms: a rapidly developing area of biotechnology for cancer therapy and other bioactivities [DOI]
- 9 Botanical Medicines for the Treatment of Cancer: Rationale, Overview of Current Data, and Methodological Considerations for Phase I and II Trials [DOI]
- 10 Anti-cancer effect of polysaccharides isolated from higher basidiomycetes mushrooms [DOI]
- 11 Effects of D-Fraction, a Polysaccharide from Grifola frondosa on Tumor Growth Involve Activation of NK Cells. [DOI]
- 12 Coriolus versicolor polysaccharide peptide slows progression of advanced non-small cell lung cancer [DOI]
- 13 White Button Mushroom (Agaricus Bisporus) Exhibits Antiproliferative and Proapoptotic Properties and Inhibits Prostate Tumor Growth in Athymic Mice [DOI]
- 14 Mushrooms of genus Pleurotus as a source of dietary fibres and glucans for food supplements [DOI]
- 15 Novel medicinal mushroom blend suppresses growth and invasiveness of human breast cancer cells [DOI]
- 16 Antitumor activity of Pleurotus ostreatus polysaccharide fractions on Ehrlich tumor and Sarcoma 180 [DOI]
- 17 Structural Characterization of β-glucans of Agaricus brasiliensis in Different Stages of Fruiting Body Maturity and their Use in Nutraceutical Products [DOI]
- 18 Quality evaluation of lentinan injection produced in China [DOI]
- 19 Antioxidant effects of a water-soluble proteoglycan isolated from the fruiting bodies of Pleurotus ostreatus [DOI]
- 20 Effects of α-glucans from Agaricus bisporus on ex vivo cytokine production by LPS and PHA-stimulated PBMCs; a placebo-controlled study in slightly hypercholesterolemic subjects [DOI]
- 21 Effects of a mushroom mycelium extract on the treatment of prostate cancer [DOI]
- 22 Antineoplastic Effect of Mushrooms: A Review
- 23 High Molecular Weight Glucan of the Culinary Medicinal Mushroom Agaricus bisporus is an α-Glucan that Forms Complexes with Low Molecular Weight Galactan [DOI]
- 24 A Phase I/II Study of a Ganoderma lucidum (Curt.: Fr.) P. Karst. Extract (Ganopofy) in Patients with Advanced Cancer [DOI]
- 25 Cancer Prevention and Treatment by Ganoderma , a Mushroom with Medicinal Properties [DOI]
- 26 The Immunostimulatory and Anti-tumor Activities of Polysaccharide from Agaricus bisporus (brown) [DOI]
- 27 Dietary Supplements from Culinary-Medicinal Mushrooms: A Variety of Regulations and Safety Concerns for the 21st Century; [DOI]
- 28 Pharmaceutical metabolites with potent bioactivity from mushrooms
- 29 Plantas y hongos comestibles en la modulación del sistema inmune
Cited by 1
Sándor Rózsa, Dănuț-Nicolae Măniuțiu, Gheorghe Poșta · Plants · 2019
Related research
- Does Pain Adversely Affect the Quality of Life in Hospitalized Cancer Patients? — shares topic coverage
- Complementary Medicine Intervention in Breast Cancer Patients with Pain — shares topic coverage
- Use of Performance Status Score for Cytotoxic Chemotherapy among Surgeons in a Tertiary Hospital, Southern Nigeria — shares topic coverage
- Breast Self Examination and Cancer Awareness among Female Staff in Federal Medical Center, Yenagoa, Bayelsa State (Knowledge and Practice) — shares topic coverage
- Assessment of Cancer Risk from Fluorscopic Bile Duct Examinations at Sanjiwani Hospital, Gianyar — shares topic coverage
Article metrics
Real usage data collected on this platform.
30
Page views
0
PDF downloads
3
Outbound clicks
1
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.