Severe Anemia Secondary to Valproic Acid Therapy in a Twelve Year Old Girl
Krishnan Balagopal, M. A. Mathew, Binu Mary Bose, Jim Alex, Shamima Ismail, Nimisha S. Nair
Asian Journal of Case Reports in Medicine and Health · pp. 54–58 · Published 21 Apr 2021
Abstract
Background: Sodium Valproate is one of the commonest antiepileptic drugs used in the paediatric age group. Haematological side effects of Valproate though rare are an important cause of morbidity. These can include anemia, red cell aplasia and thrombocytopenia. Early recognition of this complication is important for proper management. Objective: To describe a case of severe anemia caused by chronic therapy with sodium Valproate in a twelve year old girl with seizure disorder. Presentation of Case: We describe here a case of a twelve year old girl who was a known case of epilepsy on Valproate therapy presenting with severe anaemia. Haematological parameters normalized after stopping Valproate. Through this report, we wish to highlight the importance of periodic monitoring of blood counts in every patient on long term Valproate therapy.
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