Effects of Ethanol leaf extracts of Mangifera indica and Gongronama latifolium on some Haematological Parameters of Albino Wistar Rats

Abstract

The effects of ethanol leaf extracts of Mangifera indica and Gongronema latifolium on some haematological parameters (Haematocrit, HCT; Mean corpuscular Haemoglobin concentration, MCHC; Neutrophils, NEUT; Red cell Distribution width, RDW; and mixed blood cell count, MXD) in albino wistar rats were evaluated. Sixteen animals (185-223g) were assigned four groups of four rats each. Groups 1 and 3 were treated with 200mg/kg Mangifera indica and Gongronama latifolium respectively. Group 2 was treated with 200mg/kg of both plant leaf extracts at 50:50 dosage ratio. Group 4 was not treated and served as control. Treatment was done daily via oral route for one month. The animals were allowed free access to commercial rat mash and water throughout one month treatment. At the end of the treatment, no significant difference (P>0.05) was found in the HCT, MCHC and MXD levels in all the treatment groups when compared to the control. No significant difference (P>0.05) was also found among the treatment groups. NEUT levels in groups 1,2 and 3 animals recorded significant increase (P<0.05) when compared to the control but, no significant difference (P>0.05) was observed among the treatment groups. RDW recorded significant decrease (P<0.05) in groups 1,2 and 3 when compared to the control, but not significant different (P>0.05) was found among the treatment groups. These results implied that ethanol leaf extracts of Mangifera indica and Gongonema latifolium have no adverse effects on the haematological indices studied.