Vitreous Humor Glucose and Lipid Profile Levels in Rabbits Following Sodium Cyanide Exposure

Abstract

Cyanide is a fast acting, potentially and deadly chemical that can exist in various forms. This study was designed to investigate vitreous humor glucose and lipid profile levels in rabbits following sodium cyanide exposure. The rabbits were grouped into three (control, disguised and test) and the study lasted for twenty-four hours. The following parameters were investigated; fasting blood sugar (FBS), total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and very low density lipoprotein (VLDL). Data were expressed as mean ± Standard Deviation. Statistical differences between groups were computed using Graph pad prism 7.0 version. Results were analyzed using analysis of variance (ANOVA) and significance between groups was taken at p< 0.05. The results showed significant difference in concentration of FBS, TC and LDL in test group compared to the control and disguised group. However, there was no significant difference between control and disguised groups. Also, significant difference was not observed in TG, HDL and VLDL across the groups. It can be concluded that sodium cyanide is a potential poison with high toxicity effect on glucose, total cholesterol and low density lipoprotein levels and the result generated could serve as a supportive tool to autopsy findings in differentiation of death involving sodium cyanide.