Biological Study on Aerial Parts of Hyoscyamus boveanus (Dunal) Asch. & Schweinf

Abstract

Family Solanaceae is one of the largest families in the plant kingdom. A family of 98 genera and over 2700 species; tropical and temperate; herbs, shrubs or small trees. Secondary metabolites of Solanaceae plants, sharing tropane skeleton as a common structural feature, sharply divided into two classes: tropine and ecgonine derivatives. The first group, represented by well-known alkaloids: atropine and scopolamine, which are considered to be model anticholinergic drugs, continues to provide inspiration in the search for more selective muscarinic receptor antagonists. This work, aim to study the biological effect of Hyoscyamus boveanus alkaloid fraction as Antimuscarenic, mydriatic and anti microbial agent. Basal alkaloid fraction was isolated from collected wild plant by using authentic atropine (sigma USA). Fifteen rabbits weighing 1700 – 2000 gram used in this study, divided into three groups (5 each); control (solvent) group, standard (atropine) group and the Hyoscyamus boveanus Dunal basic alkaloid fraction group. Two cm rabbit intestine muscle was isolated to study anti spasmodic activity of the basic alkaloid fraction of Hyoscyamus boveanus Dunal. As well as, anti microbial activity of Hyoscyamus boveanus basal alkaloid fraction was studied. The results revealed that Hyoscyamus boveanus basal alkaloid fraction showed mydriatic, Antimuscarenic and anti microbial activity against gram negative and gram-positive bacteria. In conclusion, Hyoscyamus boveanus Dunal basic alkaloid fraction, showed mydriatic, Antimuscarenic and anti microbial activity against gram negative and gram-positive bacteria.