Effect of Toothpaste Sweeteners on Glucose Homeostasis

Abstract

Introduction: The oral mucosa, consisting of non-keratinized stratified squamous epithelium with lipids in the basal membrane, serves as a protective barrier. Its permeability can increase due to factors such as alcohol, stress, or chemicals. In this context, sweeteners, both synthetic and natural, could influence blood glucose levels, although further research is needed to understand their long-term effects. This study aims to evaluate the impact of high-Brix toothpastes on serum blood glucose levels. Methods: A prospective study was conducted with 50 participants aged 18 to 25 years. Blood glucose levels were measured before and after brushing with different toothpastes, with three measurements taken at 15-minute intervals. Results: The control group (without toothpaste) did not show a significant change in glucose level at a probability level (p= 0.5277). In contrast, the group using Arm & Hammer Truly Radiant toothpaste showed a significant difference (p= 0.0336), suggesting a potential effect on glucose level. Conclusions: Sweeteners in toothpaste may alter blood glucose levels when exposed to a standardized brushing time of 3 minutes. Further studies are needed to confirm these findings and assess their clinical implications.