Assessment of Insulin Resistance among Obese People at Shendi Locality, Sudan

Abstract

Insulin resistance (IR) is an essential factor in the etiology of type2 diabetes and is likewise related to a big range of different pathophysiologic sequelae along with hypertension, hyperlipidemia. we carried out this cross-sectional examination to the evaluation of insulin resistance in obese people. A total of 60 obese people 20% males and 80% female were divided into 4 groups overweight (20.0%), obesity class1(36.6%), obesity class2(16.6%), and obesity class3(26.6%). Blood samples were obtained from each participant and analyzed for fasting blood glucose (FBG) as well as insulin levels. Data were analyzed by using SPSS version 20. The results showed a positive correlation between insulin resistance and insulin levels (mean 1.1+0.91, 7.1+10.1, r=0.490, P. value= 0.0001 respectively). There was no correlation between insulin resistance and FBG (mean 1.1+0.91, 75.7+10.9, r=0.52, P. value = 0.691 respectively). The analysis also showed a significant positive correlation between insulin resistance and Waist-to-hip Ratio (WHR) (mean 1.1+0.91,0.92+.14, r=0.287, P. value =0.026 respectively). Additionally, there was no correlation between insulin resistance and BMI (mean 1.1+.91,36.6+9.92, r= 0.122, P. value =0.351 respectively). There was no correlation between insulin resistance and age (mean 1.1+.91, 30 +8.68, r=-0.154, P. value = 0.30 respectively). The analysis also showed a significant between insulin resistance and gender, males (mean 0.85+1.26) and females (mean 1.1+.91,0.64+0.97) which P. value=0.031. We conclude that insulin resistance in obesity has a positive correlation with fasting insulin levels and waist-to-hip ratio. Insulin resistance was more prevalent in males more than in females.