Hepatoprotective Drugs in Madanapala Nighantu: An Analytical Review

Abstract

The liver is the largest gland in the human body, that plays important vital functions. Active detoxification of the body occurs in the liver, making more prone to injuries. Hepatitis virus infection, autoimmune disease, genetic disease, cancer and other growths and metabolic diseases like NAFLD (Non alcoholic fatty liver disease), NASH (No alcoholic steatohepatitis) are the common liver disease accounts for a significant global health burden.  In Ayurveda liver disease are described in various context like yakrut vikara, kamala, pleeharoga, haleemaka. Madanapala nighandu an important Ayurvedic lexicons that mentions various hepatoprotective drugs. In Madanapala nighantu, 20 out of 525 drugs have hepatoprotective action. It is important to enlist the hepatoprotective drugs and critically analyse them according to the modern research studies done upon them. This review helps researchers to identify potential hepatoprotective plants from Ayurvedic texts and shows how many have already been validated experimentally. It provides a useful database of plants, extracts, and experimental models Analytical reviews provided traditional and ethnomedical knowledge of medicinal plant and Reverse pharmacology validate this knowledge scientifically it is helpful to save time and cost during drug discovery.