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Research Article Open access CC BY 4.0

Hepatitis E Virus among Animal Handlers and Non-Animal Handlers in Osun State, Nigeria

I. R. Gidado, F. A. Osundare, I. O. Okonko, O. O. Opaleye

Asian Journal of Advanced Research and Reports · pp. 35–48 · Published 18 Sep 2020

10.9734/ajarr/2020/v13i430316

Abstract

Aim: Increase in the epidemiological information is important for effective control of hepatitis E virus (HEV). This study was conducted to determine the prevalence of HEV among butchers, pig handlers and non-animal handlers in Osun State, Nigeria. Study Design: Cross-sectional study. Place and Duration of Study: Molecular Biology Laboratory, College of Health Sciences, Ladoke Akintola University of Technology, Isale Osun, Osogbo, Nigeria, between June 2015 and July 2019. Methods: A total of 180 blood samples were obtained and screened for HEV from cohorts of 90 animal handlers (69 butchers and 21 pig handlers) and 90 non-animal handlers. Questionnaires on HEV were administered to obtain a demographic characteristic of the participants. Anti-hepatitis E viruses were also screened using HEV ELISA kit. Results: Results showed an overall prevalence of HEV to be 21.7%. The rate of anti-HEV IgG/IgM antibodies was higher among butchers (27.5%), followed by non-animal handlers (18.9%) and was least among the pig handlers (14.3%) while the two IgM positive persons were butchers and non-animal handlers. However, 39(21.7%) of the 180 samples were positive for either anti-HEV IgG antibodies (37/180, 20.6%) or anti-HEV IgM (2/180, 1.1%). Also, the rate of anti-HEV IgG antibodies was higher among butchers (26.1%), followed by non-animal handlers (17.8%) and the pig handlers (14.3%) had the least. The two IgM positive persons were butchers (1.4%), non-animal handlers (1.1%) and pig handlers had a zero prevalence. There was no statistical significance in the prevalence of HEV IgG and HEV IgM in animal handlers as compared to non-animal handlers (P > 0.05). One (1.4%) of the butchers and 1 (1.1%) of non-animal handlers showed evidence of recent HEV infection by being positive to HEV IgM. Sources of drinking water were the only HEV predisposition factor for HEV (P =0.023). Conclusion: This study reported an acute HEV infection in a butcher and a non-animal handler in Osun State, Nigeria. No prevalence rates of acute HEV infection was observed among pig handlers in Osun State, Nigeria. The study also showed a low prevalence of anti-HEV IgG antibodies among these study populations. Proper hygiene is recommended for further reduction in HEV transmission in Nigeria.  

HEV animal handlers non-animal handlers prevalence Nigeria.

References (43)

  1. 1 Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010 [DOI]
  2. 2 Safety and Efficacy of a Recombinant Hepatitis E Vaccine [DOI]
  3. 3 Prevalence of Antibodies to Hepatitis E Virus in Veterinarians Working with Swine and in Normal Blood Donors in the United States and Other Countries [DOI]
  4. 4 Evidence of Extrahepatic Sites of Replication of the Hepatitis E Virus in a Swine Model [DOI]
  5. 5 Excretion of infectious hepatitis E virus into milk in cows imposes high risks of zoonosis [DOI]
  6. 6 Expanding Host Range and Cross-Species Infection of Hepatitis E Virus [DOI]
  7. 7 Extra-hepatic manifestations associated with hepatitis E virus infection: a comprehensive review of the literature [DOI]
  8. 8 Prevalence of Hepatitis E Virus in Chinese Blood Donors [DOI]
  9. 9 Is there evidence of recent hepatitis E virus infection in English and North Welsh blood donors? [DOI]
  10. 10 Comparative sensitivity of commercial tests for hepatitis E genotype 3 virus antibody detection [DOI]
  11. 11 Hepatitis E virus infection in patients infected with the human immunodeficiency virus [DOI]
  12. 12 Identity of a Novel Swine Hepatitis E Virus in Taiwan Forming a Monophyletic Group with Taiwan Isolates of Human Hepatitis E Virus [DOI]
  13. 13 Prevalence of antibodies to the hepatitis E virus in pigs from countries where hepatitis E is common or is rare in the human population [DOI]
  14. 14 Prevalence of antibodies to hepatitis E in two rural Egyptian communities. [DOI]
  15. 15 Hepatitis E virus infection among animals in northern India: an unlikely source of human disease [DOI]
  16. 16 Hepatitis G virus [DOI]
  17. 17 Restricted Enzooticity of Hepatitis E Virus Genotypes 1 to 4 in the United States [DOI]
  18. 18 Novel Risk Factors Associated with Hepatitis E Virus Infection in a Large Outbreak in Northern Uganda: Results from a Case-Control Study and Environmental Analysis [DOI]
  19. 19 Endemicity of Zoonotic Diseases in Pigs and Humans in Lowland and Upland Lao PDR: Identification of Socio-cultural Risk Factors [DOI]
  20. 20 Monitoring of Anti-Hepatitis E Virus Antibody Seroconversion in Asymptomatically Infected Blood Donors: Systematic Comparison of Nine Commercial Anti-HEV IgM and IgG Assays [DOI]
  21. 21 High prevalence of hepatitis E virus infection in goats [DOI]
  22. 22 Low prevalence of hepatitis E infection among pregnant women in Madrid, Spain [DOI]
  23. 23 Potential risk of zoonotic transmission from young swine to human: seroepidemiological and genetic characterization of hepatitis E virus in human and various animals in Beijing, China [DOI]
  24. 24 Seroprevalence of hepatitis E virus among blood donors in Qatar (2013‐2016) [DOI]
  25. 25 Clinical and epidemiological aspects of a hepatitis E outbreak in Bangui, Central African Republic [DOI]
  26. 26 Seroprevalence of hepatitis markers; HAV, HBV, HCV and HEV amongst primary school children in Freetown, Sierra Leone.
  27. 27 Seroprevalence and risk factors of Hepatitis E Virus infection among pregnant women in Addis Ababa, Ethiopia [DOI]
  28. 28 Hepatitis E Virus Infection: An Old Virus with a New Story! [DOI]
  29. 29 Hepatitis E virus is highly prevalent among pregnant women in Gabon, central Africa, with different patterns between rural and urban areas [DOI]
  30. 30 Increased Risk of Hepatitis E in Sewage Workers from India [DOI]
  31. 31 Hepatitis E Virus Infection among Animals and Humans in Xinjiang, China: Possibility of Swine to Human Transmission of Sporadic Hepatitis E in an Endemic Area [DOI]
  32. 32 Seroprevalence of hepatitis E virus among pregnant women and control subjects in China [DOI]
  33. 33 High hepatitis E virus antibody positive rates in dogs and humans exposed to dogs in the south‐west of China [DOI]
  34. 34 Unexpected elevated alanine aminotransferase, asparte aminotransferase levels and hepatitis E virus infection among persons who work with pigs in accra, ghana [DOI]
  35. 35 Hepatitis E virus seroprevalence in children living in rural Ghana.
  36. 36 Low seroprevalence of hepatitis E virus infection in pregnant women in Yunnan, China [DOI]
  37. 37 Hepatitis E Virus Seroprevalence and Associated Risk Factors in Apparently Healthy Individuals from Osun State, Nigeria [DOI]
  38. 38 Hepatitis E Virus Infections in Swine and Swine Handlers in Vellore, Southern India [DOI]
  39. 39 Seroprevalence and predictors of hepatitis E infection in Nigerian children [DOI]
  40. 40 A Survey on the Status of Hepatitis E Virus Infection among the Slaughterhouse Workers in Korea [DOI]
  41. 41 Acute Hepatitis E Virus Infection in Two Geographical Regions of Nigeria [DOI]
  42. 42 Serological Evidence and Risk Factors Associated With Hepatitis E Virus Infection in Pigs and Human at an Intensive Piggery Complex, Lagos Nigeria [DOI]
  43. 43 Prevalence of hepatitis E markers in primary health care antenatal attendees in Abuja, Nigeria [DOI]

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