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Research Article Open access CC BY 4.0

Hepatitis D Virus in Chronic Liver Disease Patients with Hepatitis B Surface Antigen in University of Calabar Teaching Hospital, Calabar, Nigeria

D. C. Okpokam, M. Kooffreh-Ada, Z. A. Okhormhe, E. N. Akpabio, J. O. Akpotuzor, V. U. Nna

Journal of Advances in Medicine and Medical Research · pp. 312–318 · Published 15 Dec 2014

10.9734/BJMMR/2015/14543

Abstract

Aims: It is well known that patients with hepatitis B virus (HBV) could be co-infected with hepatitis D virus (HDV), thus worsening and complicating their condition. The prevalence of HBV and HDV co-infection in University of Calabar Teaching Hospital has not been ascertained. This study was therefore carried out to determine the frequency of hepatitis D virus among chronic liver disease (CLD) patients with hepatitis B surface antigen (HBsAg) in University of Calabar Teaching Hospital, Calabar, Nigeria. Place and Duration of Study: This study was carried out in University of Calabar Teaching Hospital, Cross River State, Nigeria, from September 2012 to March 2013. Methodology: A total of 91 subjects were recruited for this study, 76 were CLD patients, while 15 were apparently healthy subjects. Sera samples were subjected to HBsAg using enzyme linked immunosorbent assay (ELISA) technique and finally the HBsAg positive and negative samples were screened using ELISA technique for hepatitis D virus. Results: Out of the 91 subjects recruited for this study, 76 (83.5%) tested positive for HBsAg, and were CLD patients. Out of the 76 CLD patients who tested positive for HBsAg, 46 (60.5%) had a co-infection with HDV, while 30(39.47%) showed no co-infection. HBV/HDV co-infection was higher in males 27(58.7%) than females 19 (41.3%). Conclusion: This study shows a high rate of HDV/HBV co-infection which was higher in males than females with chronic liver disease in UCTH, Calabar, Nigeria.

Chronic liver disease hepatitis B hepatitis D liver

References (24)

  1. 1 The Risk of Transfusion-Transmitted Viral Infections [DOI]
  2. 2 Efficacy of peginterferon alpha-2b in chronic hepatitis delta: Relevance of quantitative RT-PCR for follow-up [DOI]
  3. 3 Neoplasms of the liver [DOI]
  4. 4 Assembly of hepatitis delta virus particles [DOI]
  5. 5 Prevalence of hepatitis-B surface antigen among blood donors and human immunodeficiency virus-infected patients in Jos, Nigeria [DOI]
  6. 6 REVIEW: Hepatitis delta [DOI]
  7. 7 Epidemiology and clinical pattern of hepatitis delta virus infection in Pakistan [DOI]
  8. 8 Molecular mechanisms of gender disparity in hepatitis B virus-associated hepatocellular carcinoma [DOI]
  9. 9 Hepatitis B Surface Antigen Levels and Sequences of Natural Hepatitis B Virus Variants Influence the Assembly and Secretion of Hepatitis D Virus [DOI]
  10. 10 Treatment of chronic hepatitis D: New advances, old challenges [DOI]
  11. 11 Hepatitis B and C single and co-infection in chronic liver disease and their effect on the disease pattern.
  12. 12 Prevalence of hepatitis D in HBsAg positive patients visiting liver clinics.
  13. 13 Seroprevalence of antibody to HDV in Nigerians with hepatitis B virus-related liver diseases.
  14. 14 Prevalence of hepatitis delta antibody among HBsAg carriers in Saudi Arabia [DOI]
  15. 15 Prevalence of hepatitis delta virus infection among hepatitis b virus surface antigen positive patients circulating in the largest province of pakistan [DOI]
  16. 16 Delta hepatitis [DOI]
  17. 17 Prevalence of hepatitis B surface antigen seropositivity among HIV-infected and non-infected individuals in Nnewi, Nigeria [DOI]
  18. 18 Natural Course and Treatment of Hepatitis D Virus Infection [DOI]
  19. 19 The frequency of hepatitis D virus in patients with hepatitis B in Iran: an increasing rate? [DOI]
  20. 20 Hepatitis B viral markers in Nigerian patients with primary liver carcinoma.
  21. 21 Hepatitis D virus antigen in HBsAg positive chronic liver disease in Nigeria.
  22. 22 Hepatitis Delta Virus (HDV): Infection and Disease [DOI]
  23. 23 Co-infection of HIV and HBV among Nigerian patients and blood donors at Sagamu
  24. 24 Predicted binding affinity of candidate HDV epitope: a bioinformatics study [DOI]

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