HBV Genetic Diversity and Transfusion Safety: A Conceptual Analysis and Integrative Model
Denis Maulot-Bangola, Joseph Fokam, Christian Mangala, Thérèse Nkoa
International STD Research & Reviews · pp. 24–36 · Published 31 Aug 2022
10.9734/ISRR/2022/v11i230144Abstract
Background: Blood transfusion carry the risk of transmitting blood-borne infections. HBV genetic diversity and transfusion safety are concepts that are increasingly used in public discourse. However, how the concepts are used and how they are defined remains unclear. The objective of this study is to clarify the concepts emanating from the research project titled «Genetic diversity of HBV and its effect on the transmission risks in blood transfusion in Gabon» and to propose an integrative model of HBV genetic diversity-Transmission risks based on these results. Methods: Three databases were used in the Quantitative analysis: Pubmed, Medline and Google Scholar. The researchers delimited the search to full articles in the databases. The eligibility criteria were based on published studies in English between January 2012 and December 2020, looking at the HBV genetic diversity and the transfusion safety. The Cochrane tool was used to assess the risk of bias. A systematic review was performed on concepts and definitions. Eligible publications were reviewed using concept analysis that led to the extraction of text data for the themes “definition”, “attributes”, “antecedents”, “consequences”, and “related concepts”. The quantitative methods was used to quantify the associations between HBV Genetic diversity and transmission risk examined in the literature. Results: A total of 2685 records were identified by primary and secondary search, of which 802 were retained after examination of titles and abstracts. A total of 144 (18%) publications were included in the review, 123 dealing with Hepatitis B Virus, 38 with Genetic diversity, 94 with Transfusion safety and 94 with Transmission risks were all coded. The final concept coding scheme contained 14 items, each with a satisfactory inter-author reliability score (r) (r ranging from 0.6 and 1), coding Hepatitis B Virus, Genetic diversity, Transfusion safety, Transmission risks, Blood donation-transmission risks, Demographic factors-transmission risks, HBsAg- transmission risks, Anti-HBc-transmission risks, Viral load-transmission risks, measurement errors- transmission risks, viral load-HBsAg, viral load-Anti-HBc, Sequencing-viral load, Genotype- transmission risks. In the resulting integrative model, the elements were mapped to different levels of care. Conclusion: This integrated theory suggests a number of directions to improve the understanding of transfusion safety in the context of HBV genetic diversity, to speak the same language. It provides a basis for creating better measures and interventions in transfusion medicine.
References (53)
- 1 Home visits: a strategy to improve newborn survival - Authors' reply [DOI]
- 2 Strategies for theory construction nursing [DOI]
- 3 Chronic hepatitis B virus infection [DOI]
- 4 Update of the statements on biology and clinical impact of occult hepatitis B virus infection [DOI]
- 5 Prevention of transfusion-transmitted infections [DOI]
- 6 Update on occult hepatitis B virus infection [DOI]
- 7 Genetic variation of hepatitis B virus and its significance for pathogenesis [DOI]
- 8 Blood transfusion safety in sub‐Saharan Africa: A literature review of changes and challenges in the 21st century [DOI]
- 9 Addressing gaps in international blood availability and transfusion safety in low‐ and middle‐income countries: a NHLBI workshop [DOI]
- 10 Hepatitis B Virus Blood Screening: Need for Reappraisal of Blood Safety Measures? [DOI]
- 11 Blood transfusion in sub‐Saharan Africa: understanding the missing gap and responding to present and future challenges [DOI]
- 12 Genetic variation of occult hepatitis B virus infection [DOI]
- 13 Transfusion‐related adverse reactions: Data from the National Healthcare Safety Network Hemovigilance Module — United States , 2013–2018 [DOI]
- 14 Transfusion-Transmitted Infections and associated risk factors at the Northern Zone Blood Transfusion Center in Tanzania: A study of blood donors between 2017 and 2019 [DOI]
- 15 HIV, HCV, and HBV incidence and residual risk in US blood donors before and after implementation of the 12‐month deferral policy for men who have sex with men [DOI]
- 16 Problems and Approaches for Blood Transfusion in the Developing Countries [DOI]
- 17 Screening and diagnosis of HBV in low-income and middle-income countries [DOI]
- 18 Transfusion-Transmitted Infections Reported to the National Healthcare Safety Network Hemovigilance Module [DOI]
- 19 The Use of Rapid Diagnostic Tests for Transfusion Infectious Screening in Africa: A Literature Review [DOI]
- 20 Gaps in Viral Hepatitis Awareness in the United States in a Population-based Study [DOI]
- 21 Progress Toward Strengthening National Blood Transfusion Services — 14 Countries, 2011–2014 [DOI]
- 22 Transfusion-Transmitted Infections: an Update on Product Screening, Diagnostic Techniques, and the Path Ahead [DOI]
- 23 Concept Mapping [DOI]
- 24 Hepatitis B virus infection: Defective surface antigen expression and pathogenesis [DOI]
- 25 Hepatitis B infections among blood donors in England between 2009 and 2018: Is an occult hepatitis B infection a risk for blood safety? [DOI]
- 26 The current situation and challenges of screening for and treating hepatitis B in sub-Saharan Africa [DOI]
- 27 Distribution and Incidence of Blood-Borne Infection among Blood Donors from Regional Transfusion Centers in Burkina Faso: A Comprehensive Study [DOI]
- 28 Hepatitis B Virus Chronic Infection in Blood Donors from Asian and African High or Medium Prevalence Areas: Comparison According to Sex [DOI]
- 29 Nucleic acid testing identifies high prevalence of blood borne viruses among approved blood donors in Mozambique [DOI]
- 30 Occult hepatitis B virus infection: influence of S protein variants [DOI]
- 31 Patient blood management implementation in light of new Italian laws on patient's safety [DOI]
- 32 Prevalence, incidence and residual risk of transfusion transmitted viruses (HBV, HCV and HIV infections) in Lithuanian blood donors from 2004 to 2018: The incidence/window-period model study [DOI]
- 33 Detection of HBsAg mutants in the blood donor population of Pakistan [DOI]
- 34 Occult Hepatitis B Virus Infection and Its Risks of Cryptic Transmission in Southern Ethiopia [DOI]
- 35 Knowledge Improvement of Blood Transfusion Safety Among Pediatricians: Post Educational Intervention [DOI]
- 36 Challenges in transfusion-transmitted infection screening in Sub-Saharan Africa [DOI]
- 37 Clinical characteristics and outcomes of drug-induced liver injury in Taiwan: With emphasis on the impact of chronic hepatitis B infection [DOI]
- 38 RETRACTED: Infectivity of hepatitis B virus (HBV) surface antigen (HBsAg) positive plasma with undetectable HBV‐DNA: Can HBsAg screening be discontinued in Egyptian blood donors? [DOI]
- 39 The Investigation of HBV Pre-S/S Gene Mutations in Occult HBV Infected Blood Donors with anti-HBs Positive [DOI]
- 40 Reduction in seroprevalence of viral transfusion‐transmitted infections in southwest Nigeria in children with sickle cell disease using an enhanced screening strategy [DOI]
- 41 Applying RT-PCR standard detection procedures of HBV and HCV in Wasit blood bank [DOI]
- 42 Comparison of S gene mutations in patients with occult and chronic hepatitis B virus infection [DOI]
- 43 Occult Hepatitis B Infection [DOI]
- 44 Ensuring safe blood supply [DOI]
- 45 HBV Virus in the Future [DOI]
- 46 Abstraction and interpretation during the qualitative content analysis process [DOI]
- 47 Updating guidance for reporting systematic reviews: development of the PRISMA 2020 statement [DOI]
- 48 PNS154 THE PRISMA 2020 STATEMENT: DEVELOPMENT OF AND KEY CHANGES IN AN UPDATED GUIDELINE FOR REPORTING SYSTEMATIC REVIEWS AND META-ANALYSES [DOI]
- 49 Transfusion‐Transmitted Infections [DOI]
- 50 Chapter 12: What does the Anthropocene hold for citizenship? [DOI]
- 51 Occult Hepatitis B Virus Infection Among Blood Donors in the Capital City of Addis Ababa, Ethiopia: Implications for Blood Transfusion Safety [DOI]
- 52 Occult hepatitis B virus infections and risk factors among school-going adolescent voluntary blood donors in Kwale County Kenya, January 2020–June 2021: Cross sectional study [DOI]
- 53 Common Hepatitis B Virus Genotypes among Blood Donors in Lagos, Nigeria [DOI]
Cited by 0
No indexed citations yet.
Related research
- Determinants of Adverse Transfusion Reactions at Delta State University Teaching Hospital, Oghara, Delta State, Nigeria — shares topic coverage
- High Prevalence of Transfusion-Transmissible Infections among Volunteer Blood Donors in Rural Area of Eastern Democratic Republic of the Congo (D.R.C) — shares topic coverage
- Utility of Placental Umbilical Cord Blood in Autoimmune and Degenerative Disorders — shares topic coverage
- Haematologic Profile of Patients with Chronic Kidney Disease in Port Harcourt, South-South Nigeria — shares topic coverage
- Comparative Analysis of Haemolysis Levels in Packed Red Blood Cells Prepared via Whole Blood Settling versus Centrifugation Methods: A Study at the Zonal Blood Bank, Mbeya, Tanzania — shares topic coverage
Article metrics
Real usage data collected on this platform.
42
Page views
0
PDF downloads
7
Outbound clicks
0
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.