Evaluation of Antioxidant, Anti-inflammatory and Analgesic Activities of Leaves of Saba senegalensis (A.DC) Pichon (Apocynaceae)
Mohamed Bonewendé Belemlilga, Tata Kady Traoré, Gilchrist A. L. Boly, Noufou Ouedraogo, Aristide Traoré, Marius Lompo, Sylvin Ouédraogo, Innocent Pierre Guissou
European Journal of Medicinal Plants · pp. 1–12 · Published 12 Apr 2019
10.9734/ejmp/2019/v27i330116Abstract
Aims: To evaluate antioxidant, anti-inflammatory and analgesic activities of extracts of Saba senegalensis leaves. Study Design: In vitro antioxidant assay and in vivo anti-inflammatory, analgesic assay of Saba senegalensis extracts. Place and Duration of Study: Saba senegalensis leaves, were collected in the Centre Region of Burkina Faso, in June–July 2015. The experiments were conducted at the department of Medicine and Traditional Pharmacopeia-Pharmacy (MEPHATRA-PH) of Institute of Research in Health Science (IRSS). Methodology: The anti-oedematous tests with carrageenan and the analgesic with acetic acid and investigate effect on isolated organ were carried out. The standards were acetylsalicylic acid and paracetamol. Results: After five hours of carrageenan-induced edema test, aqueous decoction (AD) presented better inhibition on all measure. In fact, at the different doses of 200 mg/kg, 400 mg/kg, and 600 mg/kg it presented percentages of inhibitions respectively of 30.81%, 62.27% and 72.71%. For the analgesic test, the hydroethanol macerate (HEM) showed a better pain reduction compared to the AD with a maximum effect of 77.28% at 400 mg/kg. Antioxidant activity with AD and his fractions shows that AD showed a better activity for the DPPH assay with an IC50 of 1.74 ± 0.10 μg/mL and a reducing power of 59.53 ± 2.16 mmol ET/g Sample. For HEM and his fractions, the ethyl acetate fraction (FHEM-AcOEt) showed a better IC50 of 0.18 ± 0.01 μg/mL for the DPPH test and dichloromethane fraction (FHEM-DCM) a reducing power agent of 88.88 ± 2.65 mmol ET/g Sample. All fractions were endowed with antioxidant properties by both methods. Conclusion: The study findings suggest that the presence of phenolic and terpenoid compounds could explain the antioxidant, anti-inflammatory and analgesic properties of these extracts.
Cited by 11
Farzana Andleeb, Muhammad Asif, Hafiza Sidra Yaseen · Inflammopharmacology · 2022
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Brice Edie Enang II, Sylvain Nsangou Pechangou, Frederic Nico Njayou · World Journal of Advanced Research and Reviews · 2023
Hippolyte Ouedraogo, Mohamed Bonewendé Belemlilga, Aristide Traore · Pharmacology & Pharmacy · 2024
Auphedeous Yinme Dang-i, Isaac Otu Atta, Osman Haadi Mbaadawu · Heliyon · 2024
Michael Adu‑Frimpong, Isaac Otu Atta, Osman Haadi Mbadaawu · 2024
Mohamed Bonewendé Belemlilga, Bagora Bayala, Abdoul Gilchrist Laurent Boly · Natural Science · 2024
Noufou Ouedraogo, Constantin Atchade, Tata Kadiatou T · Journal of Pharmacology and Toxicology · 2020
BALLO Mahamadou, TRAORE Karim, D.A. GUINDO Abdoulaye · African Journal of Pharmacy and Pharmacology · 2023
BALLO Mahamadou N. H, Youl Estelle N.H, Traore Karim · Indian Journal of Pharmacy and Pharmacology · 2022
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