Paraoxonase-1 L/M 55 Gene Polymorphısm in the Cases of Prımer Immune Thrombocytopenıa

Abstract

Background: Oxidative stress and free-radicals could be responsible the pathogenesis and prognosis of primer immune thrombocytopenia (ITP). Paraoxonase-1 (PON-1) is an antioxidative feature. In this study, it had investigated that the role of PON-1 Leu (L)/Met (M) 55 gene polymorphism in etiopathogenesis of ITP, course of disorder and its effects of the therapy. Here, for the first time, we described polymorphisms in patients with ITP. Materials and Methods: 51 patients with newly diagnosed ITP (ND-ITP), 15 patients with chronic ITP (CH-ITP) and 60 healthy controls (HC) were investigated. Results: Most common genotype in all patients with ITP, ND-ITP and CH-ITP group, HC group was LM genotype, while MM genotype was found lower in all groups. The frequency of L allel in CH-ITP group were higher. For ND-ITP group, the frequency of M allel were higher than the frequency of CH-ITP group. Individuals with a LM genotype were found to be more resistive to anti-D therapy. It is recommended to use HDMP or IVIG for patients with LL and LM genotype and only IVIG for patients with MM genotype. Conclusion: PON-1 L/M 55 gene polymorphism in the cases of ITP displayed differences when compared those of controls. It could effect course of disorder, even might change response of treatment.