Green Tea confers Protection on the Retina in MPTP Mice Model of Parkinson’s Disease
Philemon Dauda Shallie, Koya Aderonke Kanyinsola, Oluwadamilola Faith Shallie, Omowumi Femi-Akinlosotu, Oluwole Ojo Alese, Margaret Olutayo Alese
Annual Research & Review in Biology · pp. 1–11 · Published 20 Jun 2017
10.9734/ARRB/2017/33328Abstract
Aim: This study investigated the impact of MPTP induced Parkinson’s disease (PD) and the protective and/or curative effects of green tea on the retina. Study Design: Twenty-five adult male mice (Mus musculus) weighing between 20-30 grams were used for this study. The mice were randomly placed into five groups of five mice each: A (Control; mice pellets), B (1Methyl -4-phenyl-2, 3, 6-tetrahydropyridine (MPTP) 10 mg/kg, IP), C (MPTP + Green tea (GT); 300 mg/kg GT orally), D (GT + MPTP), E (GT; 300 mg/kg). Methodology: At the end of the experimental protocols, the eyes were excised weighed and processed to determine the neurotransmitter [Dopamine, Gamma amino butyric acid (GABA) and calcium ion (CA2+)] levels in the retina spectrophotometrically and histology of the retina using Hematoxylin and Eosin (H&E) stain. Results: The results showed significant (P<0.005) reduction in the relative eye to body weight and increase in the retinal diameter in the MPTP group when compared with the control. Whereas treatments with green tea did not significantly (P<0.005) increase the relative eye to body weight but intake of green tea alone does, while the retinal diameter is significantly reduced by pre-treatment with green tea. The concentration of Calcium was significantly increased by MPTP and significantly reduced by green tea intake, whereas only the green tea alone and green tea co-treated groups significantly increased dopamine levels. Conclusion: From our results we can preliminary conclude that green tea conferred protection on the retina against the adverse effects of MPTP in mice model of Parkinson’s disease.
References (52)
- 1 MOLECULAR PATHOPHYSIOLOGY OF PARKINSON'S DISEASE [DOI]
- 2 Epidemiology and etiology of Parkinson’s disease: a review of the evidence [DOI]
- 3 Hallucinations in Parkinson's disease: Prevalence, phenomenology and risk factors [DOI]
- 4 A meta‐analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease [DOI]
- 5 Predictors of Nursing Home Placement in Parkinson's Disease: A Population‐Based, Prospective Study [DOI]
- 6 The cognitive ability of an incident cohort of Parkinson’s patients in the UK. The CamPaIGN study [DOI]
- 7 The Major Green Tea Polyphenol, (-)-Epigallocatechin-3-Gallate, Inhibits Obesity, Metabolic Syndrome, and Fatty Liver Disease in High-Fat–Fed Mice [DOI]
- 8 Prevalence of nonmotor symptoms in Parkinson's disease in an international setting; Study using nonmotor symptoms questionnaire in 545 patients [DOI]
- 9 Beneficial effects of tea catechins on diet-induced obesity: stimulation of lipid catabolism in the liver [DOI]
- 10 Mental symptoms in Parkinson's disease are important contributors to caregiver distress [DOI]
- 11 Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation [DOI]
- 12 The retina in Parkinson's disease [DOI]
- 13 Parkinson's Disease Risks Associated with Cigarette Smoking, Alcohol Consumption, and Caffeine Intake [DOI]
- 14 l-Theanine reduces psychological and physiological stress responses [DOI]
- 15 Prospective study of hallucinations and delusions in Parkinson's disease [DOI]
- 16 Dynamic Equilibrium of Neurotransmitter Transporters: Not Just for Reuptake Anymore [DOI]
- 17 Mortality and hallucinations in nursing home patients with advanced Parkinson's disease [DOI]
- 18 Memory and executive function impairment predict dementia in Parkinson's disease [DOI]
- 19 Coffee and tea consumption and the risk of Parkinson's disease [DOI]
- 20 Mitochondrial Dysfunction and Glutamate Excitotoxicity Studied in Primary Neuronal Cultures [DOI]
- 21 Calcium, Bioenergetics, and Neuronal Vulnerability in Parkinson's Disease [DOI]
- 22 Performance on the dementia rating scale in Parkinson's disease with dementia and dementia with Lewy bodies: comparison with progressive supranuclear palsy and Alzheimer's disease [DOI]
- 23 Protective Effects of Green Tea Polyphenols in the 6-OHDA Rat Model of Parkinson’s Disease Through Inhibition of ROS-NO Pathway [DOI]
- 24 Differential Effects of Black versus Green Tea on Risk of Parkinson's Disease in the Singapore Chinese Health Study [DOI]
- 25 Genetic and environmental risk factors for Parkinson's disease in a Chinese population [DOI]
- 26 The Malignant Course of “Benign Hallucinations” in Parkinson Disease [DOI]
- 27 Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task [DOI]
- 28 Depression and Parkinson?s disease [DOI]
- 29 Effect of Naturally Occurring Flavonoids on Lipid Peroxidation and Membrane Permeability Transition in Mitochondria [DOI]
- 30 Phenolic antioxidants attenuate neuronal cell death following uptake of oxidized low-density lipoprotein [DOI]
- 31 Mitochondria and neuronal glutamate excitotoxicity [DOI]
- 32 Sustained elevation of extracellular dopamine causes motor dysfunction and selective degeneration of striatal GABAergic neurons [DOI]
- 33 Selective hyposmia and nigrostriatal dopaminergic denervation in Parkinson’s disease [DOI]
- 34 Cognitive profiles of individual patients with Parkinson's disease and dementia: Comparison with dementia with lewy bodies and Alzheimer's disease [DOI]
- 35 Smoking and tea consumption delay onset of Parkinson's disease [DOI]
- 36 Ocular Motility in Parkinson's Disease [DOI]
- 37 Autonomic dysfunction in 3414 Parkinson's disease patients enrolled in the German Network on Parkinson's disease (KNP e.V.): the effect of ageing [DOI]
- 38 Epidemiology of Parkinson's disease [DOI]
- 39 Sleep disturbances and excessive daytime sleepiness in Parkinson disease: an overview [DOI]
- 40 Parkinson's Disease and Tea: A Quantitative Review [DOI]
- 41 Visual evoked potentials in parkinsonism and dopamine blockade reveal a stimulus-dependent dopamine function in humans. [DOI]
- 42 Theanine-induced Reduction of Brain Serotonin Concentration in Rats [DOI]
- 43 Clinical phenotype of subjects with Parkinson's disease and orthostatic hypotension: Autonomic symptom and demographic comparison [DOI]
- 44 Ophthalmologic features of Parkinson's disease [DOI]
- 45 Visual hallucinations in Parkinson’s disease: a review and phenomenological survey [DOI]
- 46 Long-term clinical evaluation in patients with Parkinson's disease and early autonomic involvement [DOI]
- 47 Depression in Patients with Parkinson??s Disease [DOI]
- 48 Ethical guidelines for investigations of experimental pain in conscious animals [DOI]
- 49 Book Review: GABA and Glutamate in the Human Brain [DOI]
- 50 CARLETON'S HISTOLOGICAL TECHNIQUE [DOI]
- 51 Flavonoid Antioxidants [DOI]
- 52 Studies on Experimental Models [DOI]
Cited by 0
No indexed citations yet.
Related research
- Virtual Reality–enhanced Rhythmic Auditory Cueing Versus Conventional Physiotherapy for Balance and Gait in Parkinson’s Disease: A Randomized Trial — shares topic coverage
- Virtual Reality-Based Interventions for Upper Limb Rehabilitation in Parkinson’s Disease: A Scoping Review and Critical Evidence Synthesis — shares topic coverage
- TrkA Pathway(s) are Involves in the Regulation of TRPM2 and TRPM7 Expression in the Substantia Nigra of the Parkinson’s Disease Rat Model Induced by 6-Hydroxydopamine — shares topic coverage
- Ergot Alkaloids: A Review on Therapeutic Applications — shares topic coverage
- ABO & Rh (D) Phenotypes and Alleles in the Patients with Parkinson’s Disease among the North Indian Population — shares topic coverage
Article metrics
Real usage data collected on this platform.
68
Page views
0
PDF downloads
41
Outbound clicks
0
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.