Gordon Dry Gin (Moringa Citrus Blend) Induce Adenomatous Hyperplasia in Female Sprague Dawley Rats

Abstract

Objectives: This study aim to investigate the histopathological effects of binge consumed Gordon’s dry gin moringa citrus blend on the uterus of adult female dawley Sprague rats. Materials: Fifty female rats (weighing range; 120±2.6 g - 250±3.5 g) were divided into four groups (A, B and C & D). Group A, B, C (15 animals each) were orally administered with Gordon’s dry gin moringa citrus blend, 43% ethanol, and 200 mg/kg moringa extract, respectively, while Group D (5 animals) did not receive any treatment and was used as negative control. In groups A, B, and C, five animals were sacrificed on the 7th, 14th and 21st day of administration, whereas animals of group D were sacrificed on day 21. The uterus of each rat was harvested, processed and stained with haematoxylin and eosin solution for histological analysis. Results: Results of the study revealed histological alterations in the uterus of treated animals. Such alterations include adenomatous hyperplasia and cystic hyperplasia. Conclusion: The oral administration of gordon’s dry gin moringa citrus and moringa extract at 200 mg/kg induced cystic and adenomatous hyperplasia in rat uterus, inferring that both gordon dry gin and moringa might yield antifertility activity.