Antioxidant and Anticancer Activities of Extracts and Compounds Isolated from Terminalia nigrovenulosa Plant Grown in Vietnam
Asian Journal of Biology · pp. 1–10 · Published 30 Aug 2017
10.9734/AJOB/2017/35611Abstract
This study was to isolate and identify antioxidant and anticancer compounds from extracts of bark and leaf of Terminalia nigrovenulosa. The EtOAc fraction of bark and n-BuOH fraction of leaf exhibited the highest DPPH (2,2-diphenyl-2-picrylhydrazyl hydrate) radical scavenging activity. Nuclear magnetic resonance (NMR) and mass spectra results showed that gallic acid, ethyl gallate, ellagic acid, catechin and luteolin isolated in EtOAc and n-BuOH fractions were the main components possessed DPPH radical scavenging activity. These fractions and their isolated compounds reduced human fibrosarcoma (HT1080) cell viability in a dose-dependent manner. In addition, these fractions and their isolated compounds significantly increased caspase-3 activity. Therefore, the reduction of cell viability might be due to the induction of apoptosis via caspase-3 pathway. These findings could be useful for the development of new chemotherapeutic agents for the treatment of malignant cancers from T. nigrovenulosa extracts and isolated compounds.
Cited by 0
No indexed citations yet.
Related research
- Screening of Antioxidant Activity of 20 Kinds of Mushrooms from Southwest of China — shares topic coverage
- Phenolics from Litchi chinensis Sonn. and Their Potential Antioxidant Effects — shares topic coverage
- Effect of Different Processing Conditions on Bioactive Compounds of Selected Grape Varieties — shares topic coverage
- Evaluation of the Antioxidant Properties of Some Commonly Eaten Vegetables in Akwa Ibom State of Nigeria — shares topic coverage
- Formulation and Characterization of Papaya Seed-amla Jelly Candy: A Value-added Functional Confectionery — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
0
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.