Gastroprotective Effect of Tabernaemontana divaricata (Linn.) R.Br. Flower Methanolic Extract in Wistar Rats
Journal of Pharmaceutical Research International · pp. 88–98 · Published 6 Jun 2011
10.9734/BJPR/2011/347Abstract
Tabernaemontana divaricata (L.) R.Br belonging to Apocynaceae family is traditionally used by people in many parts of the world to treat various disorders. The present study was undertaken to investigate anti-ulcer property of Tabernaemontana divaricata flower methanolic extract (TDFME 500 mg/kg, p.o) by pyloric ligation induced gastric ulceration model using Omeprazole (8mg/kg, p.o) as a standard drug in wistar rats. Five parameters i.e., volume of gastric juice, pH, free & total acidities and ulcer index were assessed. The test extract significantly (p< 0.01) decreased volume of gastric juice, free & total acidities and ulcer index. Like standard, it also raised pH of gastric acid. The observed percentage protection for standard and test were 89.84% and 79.53%, respectively. Thus, TDFME 500 mg/kg had a positive effect on all the parameters under study and the results were similar to that of standard. From the above results, it can be concluded that TDFME exhibits remarkable gastroprotective effect.
Cited by 12
Minky Mukhija, Bhuwan Chandra Joshi · Current Traditional Medicine · 2019
Dipu Samanta, Kotisree Lahiri, Madhumita J. Mukhopadhyay · CYTOLOGIA · 2015
Related research
- Investigation of Antioxidant Potential in Ocimum basilicum Flower — shares topic coverage
- Statistical Relation Nature between Climatic Variables and Soil Moisture during the Production of Cotton (Gossypium barbadense) — shares topic coverage
- Gas Chromatography-Mass Spectrometry (GC-MS) Analysis of Ethanolic Extracts of Aerva lanata (L.) — shares topic coverage
- Phramacotherapeutic Evaluation of Parmentiera cereifera Seem. (Family Bignoniaceae) Cultivated in Egypt on Albino Rats — shares topic coverage
- Infraspecific Variations and Similarities among Onion (Allium cepa L.) Varieties Using Floral and Palynological Markers — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
12
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.