Formulation, in vitro and in vivo Characterisation of Diclofenac Potassium Sustained Release Tablets Based on Solidified Reverse Micellar Solution (SRMS)
S. A. Chime, A. A. Attama, F. C. Kenechukwu, E. C. Umeyor, G. C. Onunkwo
Journal of Pharmaceutical Research International · pp. 90–107 · Published 2 Feb 2013
10.9734/BJPR/2013/1567Abstract
Aims: To formulate sustained release diclofenac potassium tablets based on solidified reverse micellar solution (SRMS) and to evaluate the in vitro and in vivo properties of the tablets. Study Design: Formulation, in vitro and in vivo evaluation of sustained release diclofenac potassium. Place and Duration of Study: Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka and Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Nigeria. Methodology: SRMS, consisting of mixtures of phospholipid and triglyceride were prepared in the ratios of 1:1, 2:1 and 1:2 (Phospholipon® 90H: Softisan® 154) respectively. SRMS-based tablets containing 100 mg of diclofenac potassium each were prepared using validated plastic mould. The physicochemical properties of the tablet formulations were studied and compared with the market brands of the drug for sustained release properties. In vitro release was carried out in simulated intestinal fluid (SIF, pH 7.5) using the USP paddle method. Anti-inflammatory, analgesic/anti-nociceptive and ulcerogenic properties of the formulated tablets were studied using adult Wistar rats. Results: The results showed that the physicochemical properties of the tablet formulations were significantly affected by the composition/ratio of the lipid matrix (LM) used (p < 0.05). The hardness of the tablets ranged from 4.55 ± 0.50 to 5.10 ± 0.39 kgf for tablets formulated with LM 1:2 and 1:1 (M3 and M1) respectively. Friability results indicated that all the SRMs tablets exhibited friability values less than 1 %. The erosion time ranged from 35.8 ± 1.10 to 120.3 ± 0.32 min. The release profile of the tablets showed maximum release between 8 – 11 h for all the batches. Diclofenac potassium tablets based on SRMS had good anti-inflammatory and analgesic properties and also inhibited the ulcerogenicity of the NSAID by up to 85 %. Conclusion: Diclofenac potassium tablets based on SRMS could be used for once daily administration.
References (19)
- 1 Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs [DOI]
- 2 The production and characteristics of solid lipid nanoparticles (SLNs) [DOI]
- 3 The Hydrophobic Barrier Properties of Gastrointestinal Mucus [DOI]
- 4 European Pharmacopoeia [DOI]
- 5 Coprocessed excipients for solid dosage forms
- 6 Preparation of novel solid lipid microparticles loaded with gentamicin and its evaluationin vitroandin vivo [DOI]
- 7 Formulation and in vitro evaluation of a PEGylated microscopic lipospheres delivery system for ceftriaxone sodium [DOI]
- 8 Drug Release from Wax Matrices I [DOI]
- 9 Gum copal and gum damar: Novel matrix forming materials for sustained drug delivery [DOI]
- 10 A novel formulation design about water-insoluble oily drug: preparation of zedoary turmeric oil microspheres with self-emulsifying ability and evaluation in rabbits [DOI]
- 11 Prediction of in vitro Drug Release Mechanisms from Extended Release Matrix Tablets using SSR/R2 Technique [DOI]
- 12 Antinociceptive and anti-inflammatory properties of Gunnera perpensa (Gunneraceae) [DOI]
- 13 Antimicrobial and anti-inflammatory activities of Olax viridis root bark extracts and fractions
- 14 Anti-inflammatory and anti-ulcerogenic activity of the ethanol extract of ginger (Zingiber officinale) [DOI]
- 15 Controlled release of solid-reversed-micellar-solution (SRMS) suppositories containing metoclopramide-HCl [DOI]
- 16 The British Pharmacopoeia [DOI]
- 17 Synthesis, ex Vivo and in Vitro Hydrolysis Study of an Indoline Derivative Designed as an Anti-Inflammatory with Reduced Gastric Ulceration Properties [DOI]
- 18 The Hydrophobic Barrier Properties of Gastrointestinal Mucus [DOI]
- 19 Brittle fracture index (BFI) as a tool in the classification, grouping, and ranking of some binders used in tablet formulation: Lactose tablets [DOI]
Cited by 18
Jeevan T. Naikwade, Vikas V. Patil, Mayur H. Katkade, Vaibhav D. Thorat, Tahir Ansari, Chetan R. Vaidya · Journal of Pharmaceutical Research International · 2013
Ikechukwu V. Onyishi, Salome A. Chime, Echezona O. Ogudiegwu · Pharmaceutical Development and Technology · 2014
Emmanuel Adelaja Bamigbola, Anthony Amaechi Attama, Franklin Chimaobi Kenechukwu · Recent Advances in Drug Delivery and Formulation · 2023
Chukwuebuka Umeyor, Emmanuel Anaka, Franklin Kenechukwu · Nanobiomedicine · 2016
Marina Kolbina, Roland Bodmeier, Martin Körber · European Journal of Pharmaceutical Sciences · 2017
Karin Becker, Sharareh Salar-Behzadi, Andreas Zimmer · Pharmaceutical Research · 2015
Showing 6 of 18 known citations — external sources report more than can currently be individually listed.
Related research
- Microbial Count of Non-sterile Pharmaceutical Products Sold in Pakistan — shares topic coverage
- Redefining the Framework for Teaching Programming to Primary School Students: Results from Three Pilot Projects — shares topic coverage
- Systemic Review of Screening the Shapes of Ibuprofen Particles in Different Solvents — shares topic coverage
- Integration of Use of Tablets into Teaching and Learning in Secondary School of Michewen District in Zanzibar — shares topic coverage
- Formulation and Evaluation of Conventional Metronidazole Tablets using Natural Gum Extracted from Grewia species — shares topic coverage
Article metrics
Real usage data collected on this platform.
21
Page views
0
PDF downloads
2
Outbound clicks
18
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.