Skip to content
Research Article Open access CC BY 4.0

First- order Derivative and UV-spectrophotometric Methods for Simultaneous Determination of Paracetamol, Ibuprofen, and Caffeine in Bulk and Parmaceutical Formulatation

Sura L. Alkhafaji, Abdulbari M. Mahood

Journal of Pharmaceutical Research International · pp. 1–14 · Published 4 Feb 2019

10.9734/JPRI/2018/46503

Abstract

Aims: This work is to develop accurate and simple spectrophotometric methods with the first derivative for estimation of Ibuprofen (IBU), Caffeine (CAF) and Paracetamol (PAR) in bulk and pharmaceutical preparation. Method: The methods use ethanol 90%: 0.1 N sodium hydroxide (25:75) as a solvent for analysis. The wavelengths were determined for each drug in the range of 200-400 nm in spectrum mode. UV-spectrophotometer-equipment used to calculate the first derivatives through which IBU, CAF, and PAR were evaluated for simultaneous assay. The validity of the methods is established on the basis of linearity, accuracy and precision, limit of detection and limit of quantification. The methods applied to estimate the level of PAR, IBU, and CAF in a capsule dosage form. Results: The linearity of the methods was in the range of (1 - 15) µg /ml at λ max 220 nm for IBU, for CAF was (1-10) µg /ml at λ max 272 nm, and for PAR was (1-16.5) µg /ml at λ max 257 nm. In the second method, by application of first derivatives, IBU has an absorbance at 212 NM (in contrast CAF and PAR have zero value at is this wavelength) whereas, CAF absorbed at 272 nm (in contract IBU and PAR have zero value at this wavelength) whereas PAR has absorbance at 230 nm (in contrast IBU and CAF has zero value). Upon derivative assay, the amount was 98.58 %, 98.15% and 98.66% for PAR, IBU, and CAF, respectively. Conclusion: The suggested methods can be effectively applied for simultaneous determination of IBU, CAF and PAR in the bulk and capsule dosage form with good precision, recovery and less percentage of error.

Ibuprofen paracetamol caffeine first order derivative UV- spectrophotometry

Cited by 31

A new gas chromatographic method development and validation for the simultaneous determination of ibuprofen and caffeine in bulk and pharmaceutical dosage form

Celine Zambakjian, A. Sakur · Future Journal of Pharmaceutical Sciences · 2020

UV SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF PALBOCICLIB IN BULK AND IN-HOUSE CAPSULE FORMULATION

R. D. Rathod, A. Mundada, H. Patel · Indian drugs · 2020

RP-HPLC and UV Spectrophotometric Analysis of Paracetamol, Ibuprofen, and Caffeine in Solid Pharmaceutical Dosage Forms by Derivative, Fourier, and Wavelet Transforms: A Comparison Study

Hoang Vu Dang, Hương Trương Thi Thu, Ly Dong Thi Ha · Journal of Analytical Methods in Chemistry · 2020

Simultaneous Ratio Derivative Spectrophotometric Determination of Paracetamol, Caffeine and Ibuprofen in Their Ternary Form

Khalaf F. Alsamarrai, S. T. Ameen · Baghdad Science Journal · 2022

Photocatalytic degradation of pharmaceuticals using natural sand-based TiO2 catalysts: Preparation, characterization, and reactivity

Abdessalim Chahid, Brahim Zahraoui, Driss Lahcene · Journal of Photochemistry and Photobiology A: Chemistry · 2025

Evaluation of in silico and in lab sample enrichment techniques for the assessment of challengeable quaternary combination in critical ratio

Dina A. Ahmed, Hayam M. Lotfy · Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy · 2021

A MODEST UV SPECTROPHOTOMETRIC ASSISTED BY CHEMOMETRIC APPROACH FOR VERIFICATION OF ACETAMINOPHEN LEVEL IN VARIOUS MANUFACTURED TABLETS AND SYRUPS IN INDONESIAN PHARMACIES

MUHAMMAD ABDURRAHMAN MUNIR, AHLAM INAYATULLAH, SOFIAN IBRAHIM · International Journal of Applied Pharmaceutics · 2023

A Novel Inner Time and Outer pH-Dependent Dual Coated Multi-Particulate Approach for Colon Specific Delivery of Ibuprofen Beyond Ileocecal Segment in Reduced Colonic Bacterial Diversity

Debaprasad Ghosh, Nikhil Kumar Singh, Ashu Mittal · 2026

Development and Validation of a UV Spectroscopic Method for the Estimation of Gepirone Hydrochloride in Bulk and Tablet Dosage Form in Dissolution Media

Rajlaxmi Patro, Subrata Mallick, Ch.Niranjan Patra · Journal of Applied Spectroscopy · 2025

Showing 19 of 31 known citations — external sources report more than can currently be individually listed.

Related research

Article metrics

Real usage data collected on this platform.

10

Page views

0

PDF downloads

5

Outbound clicks

31

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.