Facile Synthesis and Characterization of New 2,3-Disubstituted Benzimidazole Derivatives
Olayinka O. Ajani, Emmanuel K. Ezeoke, Abiola Edobor-Osoh, Alice O. Ajani
International Research Journal of Pure and Applied Chemistry · pp. 10–21 · Published 8 Feb 2013
10.9734/IRJPAC/2013/2480Abstract
Benzimidazoles are known to represent a class of medicinally important compounds which are extensively used as antibacterial agents. Hence, a series of five 2-substituted benzimidazole precursors (1a-e) were synthesized via [4 + 1] condensation and imino compound (1f) by simple condensation in the presence of Conc. HCl as catalyst. Synthetic modification of N-1 position was achieved in order to obtain new 5-chloro-2,4-dinitrophenyl bearing 1,2-disubstituted benzimidazole 2a-e and 2f, and 3-chlorobenzyl bearing 1,2-disubstituted benzimidazole 3a-e and 3f in good to excellent yields using a facile approach. The chemical structures of all synthesized compounds were confirmed using spectroscopic means such as UV-visible, IR, Mass spectra, 1H and 13C NMR as well as C, H, N elemental analytical data.
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Cited by 14
Olayinka O. Ajani, Olayinka O. Tolu-Bolaji, Shade J. Olorunshola · Journal of Advanced Research · 2017
Caixia Xie, Xushuang Han, Jian Gong · Organic & Biomolecular Chemistry · 2017
Leqaa A. Adnan, Nuaman F. Alheety, Abdulwahhab H. Majeed · Materials Today: Proceedings · 2021
Sabikeh G. Azimi, Ghodsieh Bagherzade, Mohammad Reza Saberi · Bioinorganic Chemistry and Applications · 2023
L. N. Divaeva, A. I. Klimenko, A. S. Morkovnik · Pharmaceutical Chemistry Journal · 2015
Olayinka O. Ajani, Damilola V. Aderohunmu, Chinwe O. Ikpo · Archiv der Pharmazie · 2016
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