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Research Article Open access CC BY 4.0

Expression Patterns of ER, PR, Her2/neu, and Ki67 in Sudanese Breast Cancer Patients

Tumadir Mohamed Adam Ali, Mohamed Mahgoub Hassan Khalifa, Ahmed Abdalla Agab Eldour, Sirelkhatim Merghani Elkheir Mohammed, Hussain Gadelkarim Ahmed

Journal of Cancer and Tumor International · pp. 162–169 · Published 14 Dec 2024

10.9734/jcti/2024/v14i4277

Abstract

Background: Tumor markers are crucial indicators for breast cancer treatment and follow-up. Thus, this study attempted to explore the expression patterns of ER, PR, Her2/neu, and Ki67 in Sudanese breast cancer patients. Methodology: This study was a retrospective descriptive analysis conducted in El-Obeid city, Sudan. Records of 190 patients were obtained, including 110 with malignant lesions and 79 with benign breast lesions, from two histopathology laboratories. Results: Approximately 37% of patients were ER/PR positive, whereas 31% of cases tested for ER, PR, and Her2/neu were classified as triple negative. Ki-67 expression exhibited significant variability among breast lesions. Invasive ductal carcinoma (IDC) exhibited the highest expression of estrogen receptors (ER) at 59%, followed by progesterone receptors (PR) at 56%, and HER2 positivity at 53.8%. Conclusion: Breast cancer cases in Sudan are prevalent, characterized by ER/PR positivity, triple-negative status, and elevated Ki-67 expression. The predominant histological type of breast cancer is invasive ductal carcinoma. Women under the age of 45 exhibit a higher susceptibility to breast cancer. A significant number of patients exhibit advanced stages of the disease. Sudan advocates for the prevention and early detection of breast cancer.

Breast cancer invasive ductal carcinoma estrogen receptors progesterone receptors triple-negative breast cancer

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