Evaluation of Thyroid and Thyroid Stimulating Hormone Status to the Diagnosis of Differential Thyrotoxicosis

Abstract

Aims/ Objectives: To study the thyroid and thyroid stimulating hormone levels of clinical and subclinical thyrotoxicosis patients. Study Design: Cross-sectional study. Place and Duration of Study: Institute of Nuclear Medicine and Allied Sciences (INMAS), Rajshahi Medical College Hospital, Rajshahi, between May 2013 and April 2014. Methodology: In total, 239 assays are performed in 83 thyrotoxicosis patients. Biochemical confirmation of thyrotoxicosis is based on the finding of a suppressed TSH in combination with elevated serum total or free T4 and T3 levels. The serum TSH was measured using standard immunoradiometric assay technique whereas serum T4 and T3 by the method of radioimmunoassay. Results: The present study observes that the most common cause of thyrotoxicosis is Graves’ disease, followed by thyroiditis, toxic adenoma, and multinodular goiter. The Graves’ disease is found to be approximately 2.5 times more common in women than in men. It is also noticeable that majority of the patients with Graves’ disease are predominantly in the younger age groups. Conclusion: The present results produce fairly a good agreement with the reported data and, therefore, will provide a guideline for the diagnosis and management of clinical and subclinical thyrotoxicosis.