Skip to content
Research Article Open access CC BY 4.0

Evaluation of the Suspending Properties of a Novel Hydrophilic Biopolymer Derived from the Tubers of Ipomoea batatas on Sulphamethoxazole Suspension

Ugoeze Kenneth C., Nwachukwu Nkemakolam

Journal of Advances in Medical and Pharmaceutical Sciences · pp. 1–8 · Published 4 Nov 2017

10.9734/JAMPS/2017/37028

Abstract

Aims: This work examines a novel hydrophilic biopolymer, I-polygel derived from Ipomoea batatas tubers (Convolvulaceae) as a suspending agent in sulphamethoxazole suspension using acacia and tragacanth respectively as comparing standards. Methods: Aqueous suspensions of sulphamethoxazole containing 1, 2, 4 or 5% w/v of I-polygel, acacia or tragacanth respectively were prepared and evaluated using sedimentation volume, rheology, viscosity, free-thaw cycle and redispersibility tests. Results: Sedimentation volume was proportional to the concentrations of suspending agents across the preparations with the suspensions containing I-polygel exhibiting more consistency: I-polygel > acacia > tragacanth > control (P = 0.000). The flow rates were inversely proportional to the concentrations of the respective suspending agents whereas the reverse was the case with viscosity. There was no impediment to the flow of the suspensions at the concentrations of the suspending agents employed. The suspensions containing I-polygel indicated higher viscosities in all the concentrations: I-polygel > acacia > tragacanth > control (P = 0.000). There was no significant particle size increase before and after the freeze-thaw cycle test, showing that sulphamethoxazole may be stable in the presence I-polygel, acacia and tragacanth. All the preparations containing I-polygel was redispersed with the minimal shear stress: I-polygel < acacia < tragacanth < control (P = 0.000). Conclusion: The application of a newly developed hydrophilic polymer, I-polygel as a suspending agent in comparison to acacia and tragacanth in the formulation of sulphamethoxazole suspensions yielded a more consistent and stable suspension with statistically proven higher  sedimentation volume,  better rheological properties, higher viscosities and ease of redispersion of suspension with minimal shear stress. 

Hydrophilic biopolymer I-polygel Ipomoea batatas acacia tragacanth suspension sulphamethoxazole

References (7)

  1. 1 Chemistry of Tropical Root Crops: Significance for Nutrition and Agriculture in the Pacific [DOI]
  2. 2 HPLC Determination of Sugars in Raw and Baked Sweet Potatoes [DOI]
  3. 3 Stability Studies Needed to Define the Handling and Transport Conditions of Sensitive Pharmaceutical or Biotechnological Products [DOI]
  4. 4 Complexation and Protein Binding [DOI]
  5. 5 The suspending properties of Terminalia randii gum in magnesium carbonate suspension [DOI]
  6. 6 The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals [DOI]
  7. 7 Sweet potato: an untapped food resource [DOI]

Cited by 8

Physicochemical Characterization and Evaluation of the Suspending Properties of Boswellia papyrifera Gum in Metronidazole Benzoate Suspension

Gebremariam Woldu, Tsegay Brhane, Gebre Teklemariam Demoz · BioMed Research International · 2024

Showing 1 of 8 known citations — external sources report more than can currently be individually listed.

Related research

Article metrics

Real usage data collected on this platform.

63

Page views

0

PDF downloads

41

Outbound clicks

8

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.