Evaluation of Some Renal Function Parameters in Female Subjects with Uterine Fibroid in Port Harcourt, Nigeria

Abstract

Uterine fibroids are the commonest gynaecological conditions that affect a good number of women globally. This study evaluated renal assessment parameters among female subjects with uterine fibroids. The study involved 80 subjects with uterine fibroids and 60 control subjects, within the age range of 20 and 50 years. Subjects were selected using simple random sampling technique. Blood samples (10 ml) were collected from each subject via venipuncture, and put into plain bottles for the analysis of electrolytes (using ISE technique) and urea, creatinine and bicarbonate (using biochemistry autoanalyzer). Results from this study showed that the mean levels of sodium (140.83 ± 0.38 mmol/l), chloride (106.44 ± 0.31 mmol/l), urea (5.66 ± 0.19 mmol/l) and creatinine (85.81 ± 1.20 µmmol/L) were significantly higher in the subjects with uterine fibroids compared to the mean levels of the same parameters (sodium-135.50 ± 0.66 mmol/l, chloride-99.03 ± 1.32 mmol/l, urea-4.57 ± 0.17 mmol/l and creatinine-70.30 ± 0.89 µmmol/L) in the control subjects. Conversely, the mean level of potassium (mmol/l) in the uterine fibroid subjects (4.21 ± 0.13 mmol/l) was significantly lower than the level in the control subjects (4.85 ± 0.14 mmol/l). There was no significant difference in the bicarbonate levels. There were also no significant differences in the parameters among the subjects with uterine subjects based on the duration of condition, consumption of alcohol, exercise and medical treatment. The study shows that there are alterations in renal assessment parameters among uterine fibroid subjects. Women are encouraged to seek regular medical checkups in order to ensure early management of renal impairments in uterine fibroid.