Evaluation of Injectable Platelet-rich Fibrin (i-PRF) as an Autologous Tissue Regenerator in Facial Aesthetics

Abstract

Introduction: Cutaneous ageing, an inherent process with advancing time, often detrimentally impacts self-esteem due to manifestations like wrinkles, blemishes, dehydration, sagging, and reduced tissue vitality. A contemporary trend seeks natural approaches to facial rejuvenation. Injectable Platelet-Rich Fibrin (i-PRF) emerges as a noteworthy solution owing to its biological origin and autologous nature. Materials and Methods: Evaluating i-PRF's efficacy in counteracting ageing signs, we employed a 16 MHz high-frequency ultrasound device and meticulous photographic documentation. 26 females, aged 35-55, underwent three i-PRF sessions. Statistical scrutiny utilised a paired t-test (α = 0.05) to assess dermal modifications. Self-Perception Index scores underwent Wilcoxon testing (α = 0.05) for significant enhancements. Comparisons of newly captured frontal and profile photographs (D and E) with initial images aided visible change assessment. Results and Discussion: Compelling data analysis evidenced a notable dermal thickness increase post-intradermal i-PRF application. P-values for examined regions were: glabella (P < .00269), frontal D (P < .00018), frontal E (P < .00014), cheek D (P < .00709), and cheek E (P < .0008). These results underscore substantial dermal thickness alterations. Statistical examination of the Self-Perception Index yielded a P-value < .0001, signifying significant self-perception change post-treatment. Conclusion: Intradermal i-PRF application markedly increased dermal thickness, endorsing its potential for dermal restructuring. Furthermore, this approach presents an accessible, cost-effective, and unbiased alternative for facial rejuvenation.