Evaluation of in-vitro Anti-ulcer Potential of Aerial Parts of Crossandra infundibuliformis Linn

Abstract

Ulcer formation in humans may be precipitated by a range of factors, including psychological stress and the prolonged use of anti-inflammatory medications. Although the aetiology remains undefined in many cases, it is widely accepted that ulcer development arises from an imbalance between aggressive factors and the mechanisms responsible for maintaining mucosal integrity via endogenous defence systems. To evaluate the anti-ulcer activity of Crossandra infundibuliformis linn extract using an In-vitro experimental study. This study examined the potential of ethanol extract of Crossandra infundibuliformis to block H+/K+ ATPase in order to determine whether it may be utilized to cure ulcers.  It involved evaluating the acid-neutralizing capacity of different concentrations of extracts with a standard antacid. The extract significantly reduced acid neutralizing capacity to 25 at a concentration of 500 μg/ml as compared to 45 with standard Aluminium hydroxide + Magnesium hydroxide (50 mg/ml). While in H+ /K+ - ATPase inhibition activity, the extract showed maximum percentage inhibition of 71.76% at the concentration 500μg as compared to 90.66% with standard Omeprazole. The results of this study suggest that Crossandra infundibuliformis ethanol extract contains substances that can block enzymes and neutralize acids, making it a better treatment for digestive issues.