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Research Article Open access CC BY 4.0

Evaluation of Changes in Biochemical and Haematological Parameters of Albino Rats Following Subacute Oral Administration of Cinnamomum cassia (Cinnamon) Extract

C. N. Okwuosa, N. C. Azubuike, C. P. Okorie

Annual Research & Review in Biology · pp. 91–99 · Published 9 Jul 2021

10.9734/arrb/2021/v36i630393

Abstract

Background: Cinnamomum cassia stem bark is used traditionally for the treatment of digestive disorders, diabetes and to alleviate symptoms of cold or flu. Aim: The present study evaluated biochemical and haematological changes in male albino rats after exposure to the stem bark ethanolic extract of Cinnamomum cassia (SBECC). Study Design: An experimental study which lasted for 19 days. Place and Duration of Study: Department of Medical Laboratory Sciences and Animal House, College of Medicine, University of Nigeria, Enugu Campus, between April 2019 and August 2019. Methodology: Twenty (20) rats weighing 130-170 g were used. Graded doses (100, 200 and 400mg/kg body weight) of the SBECC were orally administered to the animals in groups B, C and D respectively, once daily for 18 days. Group A served as the normal control and received only the vehicle (5ml/kg of 0.25N sodium carbonate). On Day 19, body weights of the rats were measured and blood samples obtained via retro-orbital puncture, were placed into plain tubes and tri-potassium ethylene diamine tetra-acetic acid (K3EDTA) containers for biochemical and haematological studies respectively. Results:  Weight gain was observed in all treatment groups and control. The highest and lowest percentage weight gain was observed in Group C (51%) and Group B (33%) respectively. All the doses of the extract significantly decreased serum cholesterol levels when compared to the control (P<0.05). Treatment with 400mg/kg SBECC (Group D) significantly increased serum Alkaline phosphatase (224.00±12.88iu/l) and creatinine levels (85.60±7.40) when compared to the control (140.00±26.47 and 63.60±7.60 respectively) (P<0.05), whereas treatment with 200mg/kg SBECC significantly increased urea and creatinine levels (P<0.05). No significant changes were observed in the haematological parameters of the treated rats compared to the control. Conclusion: Sub-acute oral administration of Cinnamomum cassia stem bark extract at doses lower than 500 mg/kg may not exert toxic effects on haematological parameters but can alter some serum biochemical parameters in rats.

Cinnamomum cassia sub-acute studies toxicology biochemical and haematological parameters

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