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Research Article Open access CC BY 4.0

Evaluation of CD4 T Lymphocyte Cell Levels among Hepatitis B, C and E Viruses Negative Individuals in Ibadan, Southwestern Nigeria

M. O. Adewumi, E. C. Omoruyi, I. M. Ifeorah, A. S. Bakarey, A. O. Ogunwale, A. Akere, T. O. C. Faleye, J. A. Adeniji

Microbiology Research Journal International · pp. 1–8 · Published 12 Jan 2018

10.9734/MRJI/2017/38401

Abstract

Aim: The CD4 T lymphocytes play a key role in achieving a regulated effective immune response to foreign antigens. It is also a valuable parameter for assessing HIV disease progression. However, variations in CD4 T lymphocyte values due to diverse factors have been reported. Here we evaluated CD4 T lymphocytes among community dwellers who tested negative for hepatitis B, hepatitis C and hepatitis E viruses and compared the results with the National Reference Values (NRVs).  Study Design: A cross-sectional study was conducted. Participants were enrolled using a convenient sampling technique and their socio-demographic characteristics were captured by administration of semi-structured questionnaires. Place and Duration of Study: This study was conducted among residents of Ibadan metropolis, Southwestern Nigeria. Participants were enrolled between July and September, 2013 at the University College Hospital, Ibadan. Methodology: Four hundred consenting participants who fulfilled the criteria for enrolment were evaluated for CD4 T lymphocyte counts. Results: Estimated mean CD4 T lymphocyte count of 1,183 (CD4 Range: 328-2680) cells/µl of blood was recorded for the participants. Four (1.0%), 151 (37.8%), 157 (39.2%), 74 (18.5), and 14 (3.5) of the participants had CD4 T lymphocyte count ranged 352-500, 501-1,000, 1,001-1500, 1501-2,000, and >2,000 cells/µl of blood, respectively. Differences in the estimated mean CD4 count between different age groups varied significantly (P=0.010). Conclusion: In this study, significantly higher CD4 T lymphocyte values were observed among the study population in comparison to the NRVs, and consequently we advise careful interpretation and use of extrapolated CD4 T lymphocyte values in the management of persons with diverse geographical background or health conditions.

CD4 T lymphocyte HBV HCV HEV HIV Nigeria

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