Evaluation of Biochemical Aspects of Formulated Drugs against Typhoid

Abstract

Typhoid fever one of the major health problems in many developing countries. Salmonella is a gram-negative, rod-shaped facultative anaerobic bacterium. Salmonella has developed resistance to many antibiotics used now a day that has complicated its management, that thus it has necessitated the search of formulated drugs for its treatments. Nitric oxide (NO) is an important signaling molecule that regulates a diverse range of patho-physiological processes in many tissues. Earlier studies have suggested that exogenous administration of Larginine results in increased NO production, indicating that endogenous substrate is insufficient for maximal NO production. Taking these facts in to consideration, it was thought pertinent to see the effect of oral administration of NO precursor, i.e., L-Arginine. Bacterial Clearance Study shows the bacterial burdens in the liver of S. typhimurium infected mice were consistently greater as compared to formulated drugs (L-Arginine+Ciprofloxacin) treated mice and ALT and AST decreases by 38.84% and 53.61% in 1/2 L-Arg+1/2 Cip group as compared to bacterial treated groups.