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Research Article Open access CC BY 4.0

Estimation of Drug Pharmacokinetics from Breast Feeding: A Simple Method Based on Meta-analysis

Oumar Aboubacar Alassane, De Pablos-Martinez Carlos, Maiga Mamoudou, Dao Sounkalo, Chatelut Etienne, Gandia Peggy

Journal of Advances in Medical and Pharmaceutical Sciences · pp. 1–8 · Published 3 Aug 2019

10.9734/jamps/2019/v21i230126

Abstract

Background: In resource-limited settings, breastfeeding is the healthiest source of nutrition for newborns. For economic/cultural reasons, breastfeeding is the preferred option for the majority of mothers, including HIV-positive mothers. Objective: The objective of this review is to document parameters characterizing antiretroviral therapy (ARV) diffusion into breast milk associated with the estimated ARV amount ingested by breastfed infant and clinical/biological abnormalities. Data Source and Eligibility Criteria: Twenty seven (27) published articles on the aspects of Pharmacokinetic parameters on ARV diffusion into breast milk have shown a large variability without clear interpretation on drugs diffusion. Using PubMed and Embase, we conducted a search to identify all published studies at 2015 that characterized antiretroviral drug diffusion from mother to infant via breast milk. We identified 27 published studies that characterized antiretroviral drug passage from mother to infant (drug concentrations in mother’s milk and breastfed plasma). Information was sufficiently complete for inclusion in the present analysis for only six antiretroviral drugs. Results: Finally, only data for nevirapine and efavirenz were exploitable because some of the studies found null or non-detectable levels, which were not suitable for simulations. Median (IQR) nevirapine CL/F were 0.022 (0.013-0.038) for newborns, 0.121 (0.116-0.125) for children and 0.056 (0.045-0.070) for mothers, all in L/h/kg. Efavirenz CL/F were 0.025 (0.016-0.039) for newborns, 0.273 (0.261-0.285) for children and 0.160 (0.153-0.167) for mothers, also in L/h/kg. Conclusion: Pharmacokinetics parameters of efavirenz and nevirapine are important to be determined in breastfed newborns.

Breast milk antiretroviral drugs newborn exposure.

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Cited by 2

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L. Kuhn, M. Paximadis, B. Da Costa Dias · Clinical Infectious Diseases · 2021

Predictors of Cell-Associated Human Immunodeficiency Virus (HIV)-1 DNA Over 1 Year in Very Early Treated Infants.

Kuhn L, Paximadis M, Da Costa Dias B · Clin Infect Dis · 2022

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