In-vivo Antibacterial and Synergetic Effect of Garlic (Allium sativum Linn) and Water Lilies (Nymphae lotus Linn) Extracts on Multi-Drug Resistant Enteric Bacteria

Abstract

Enteric bacterial pathogens are the major causes of food-bourne diseases and remains a crucial global health concern. The emergence of multi-drug resistant enteric bacterial has been a major public health concern especially in developing countries of the world. The in-vivo antibacterial and synergetic effect of garlic (Allium sativum Linn) and water lilies (Nymphae lotus Linn) extracts on multi-drug resistant enteric bacteria was examined using experimental mice obtained from animal house, College of Medicine, Obafemi Awolowo University, Ile-Ife, Nigeria in accordance with laboratory practice regulation and the principle of humane laboratory animal care. The histological effects of treatment with water extract of A. sativum, ethanol extract of N. lotus and combination of water extract of A. sativum and ethanol extract of N. lotus at ratio 1:1 on organs invasion of Salmonella showed that major pathological effects were exerted on the liver and kidney of mice. The findings for this study suggests that the extracts of N. lotus and A. sativum may be used as antibacterial agents in the management of infections that may occur as a result of consumption or contact with faecally impacted surface waters.