Psoriasis and Metabolic Syndrome: A Gender Case-Study Clinical Correlation

Abstract

Background: Metabolic syndrome (MS) and Psoriasis are chronic inflammatory conditions resulting from multifactorial pathogenesis comprising hereditary and environmental factors. The main common factor to link these conditions is Intestinal Hyper permeability (IHP), also known as the Leaky Gut Syndrome (LGS. The gender predisposing for Non Alcoholic Fatty Liver Disease (NAFLD) in psoriasis is main objective of the study. Methods: Metabolic syndrome was diagnosed by ultrasonic evidence of non-alcoholic fatty liver (NAFLD) in psoriatic patients and asymptomatic control.  All the collected information put into predesigned Performa. The data was entered and analysed using SPSS v23.0. Mean± Standard Deviation (SD) of age, duration of disease Psoriasis Area and Severity Index (PASI) Score, Body Surface Area, frequency and the percentage of non-alcoholic fatty liver and gender. Two groups, cases and controls, were compared to assess association between psoriasis and non-alcoholic fatty liver and Chi square test was applied. P value ≤ 0.05 was considered as a significant. Odds ratio was calculated at 95% of confidence level. Results: In gender wise distribution of cases and control 65 (65%) male and 61 (35%) female were included in cases and 75 (65%) male and 36 (35%) female were included in control group. Compared to control the odd of non-alcoholic fatty liver was found to be more prevalent in males as compared to the females (OR=3.42, CI 1.624 to 7.201, p-value <0.00). Conclusions: The rate of NAFLD is significantly increased in concerning control cases and it was 2 times more likely in male cases as compare to female.