Effects of Centella asiatica Administration on NT-3 and CDKN2A Levels in Adult Rat Brains
Ninik Mudjihartini, Reni Paramita
Asian Journal of Medicine and Health · pp. 173–178 · Published 26 Dec 2022
10.9734/ajmah/2022/v20i12780Abstract
Aims: This study aims to determine at the effect of Centella asiatica L. (CA) on Neurotrophin-3 (NT-3) brain level and Cyclin-dependent kinase inhibitor 2A (CDKN2A) brain level of rats aged 12, 24 and 36 weeks. Study Design: Experimental studies used rats aged 12, 24, and 36 months which were treated with CA extract 300 mg/BW was administered orally for 29 days in a row as described in previous study. In addition, untreated rats aged 12, 24, and 36 months were used as negative controls. Place and Duration of Study: Department of Biochemistry and Biology Molecular, Faculty of Medicine, Universitas Indonesia. Methodology: NT-3 and CDKN2A brain levels were measured using the ELISA method. Results: The results showed a significant decrease in NT-3 levels in rats aged 36 weeks that were given CA compared to control rats (Sidak multiple comparison test; P = .0493). In addition, the CDKN2A levels of CA-treated rats aged 36 weeks that were compared to control rats (Sidak multiple comparison test, P = .0041). Conclusion: This study proved that giving CA 300mg/kgBW for 29 days in adult rats aged 36 weeks has not been able to prevent aging in terms of NT-3 and CDKN2A proteins.
References (22)
- 1 Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders [DOI]
- 2 An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA [DOI]
- 3 Ink4a/Arf expression is a biomarker of aging [DOI]
- 4 Pharmacological review on Centella asiatica: A potential herbal cure-all [DOI]
- 5 Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging [DOI]
- 6 Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model [DOI]
- 7 Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review [DOI]
- 8 The Tumor Suppressor Protein p16INK4a [DOI]
- 9 The Free Radical Theory of Aging Is Dead. Long Live the Damage Theory! [DOI]
- 10 Age-related changes in glutathione and glutathione-related enzymes in rat brain [DOI]
- 11 Centella asiatica(L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential [DOI]
- 12 Real-time in vivo imaging of p16Ink4a reveals cross talk with p53 [DOI]
- 13 Regulation of Brain-Derived Neurotrophic Factor Gene Expression after Transient Middle Cerebral Artery Occlusion with and without Brain Damage [DOI]
- 14 Chemical constituents ofCentella asiatica [DOI]
- 15 Hepatoprotective Effects of Acalypha Indica and Centella Asiatica in Rat's Liver Against Hypoxia [DOI]
- 16 Centella asiatica Improves Physical Performance and Health‐Related Quality of Life in Healthy Elderly Volunteer [DOI]
- 17 Effect of NT-3 on infection-induced memory impairment of neonatal rats. [DOI]
- 18 The nerve protection and in vivo therapeutic effect of Acalypha indica extract in frogs [DOI]
- 19 Hypoxia-regulated neurotrophin-3 expression by multicopy hypoxia response elements reduces apoptosis in PC12 cells [DOI]
- 20 Comparing Anti Aging Potential Between Centella asiatica and Acalypha indica: Focus on Forelimb Muscle Strength [DOI]
- 21 Acalypha indica Linn root extract improved hippocampal cell viability and increased brain-derived neurotrophic factor (BDNF) in hypoxic condition [DOI]
- 22 Comparing the effect of Centella asiatica L. and Acalypha indica L. treatment to carbonyl and glutathione level in the brains of old rats [DOI]
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