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Research Article Open access CC BY 4.0

Effect of Using Midazolam and Propofol in Low Doses for Intraoperative Nausea and Vomiting Prevention in Pregnant Women Underwent Cesarean Section under Regional Anesthesia

Zainab Faisal Habasha

Asian Journal of Medicine and Health · pp. 1–6 · Published 14 Jul 2023

10.9734/ajmah/2023/v21i10872

Abstract

Aim: To investigate if and how severe intraoperative nausea and vomiting occur following elective cesarean sections performed under spinal anesthesia using sub-hypnotic dosages of midazolam and propofol. Study Design: Clinical trial. Methodology:  The current study was conducted at the Gynecology and Obstetrics Department of a Teaching Hospital in Baghdad, Iraq. The study included 90 full-term pregnant women with single viable fetuses who underwent elective C/S by spinal anesthesia and were randomly assigned to one of three groups: group A included 30 women who received propofol, group B included 30 women who received midazolam, and Group C included 30 women who received placebo. The Bellville scoring score was used to assess nausea and vomiting. The Richmond Agitation Sedation Score (RASS) was used to assess sedation intraoperatively. Results: Patients in group C had the highest prevalence of nausea and vomiting (56.7%), which was significantly different from groups A (16.7%, P=0.001) and B (13.3%, P=0.001); however, there was no statistically significant difference between groups A and B (P= 0.717). The group B patients had the highest prevalence of drowsiness (20%), which was substantially different from group C (3.3%, P=0.044), whereas there were no statistically significant differences between groups A and B (P= 0.278) or A and C (P= 0.3). Conclusion: Low doses of midazolam or propofol administered after cesarean section (after the umbilical cord has been clamped) can lessen intraoperative nausea and vomiting without significantly lowering blood pressure or heart rate, with midazolam being more effective than propofol in this regard.

Spinal anesthesia propofol midazolam IONV C/S Iraq

References (12)

  1. 1 Preventing nausea and vomiting in women undergoing regional anesthesia for cesarean section: challenges and solutions [DOI]
  2. 2 Subhypnotic doses of midazolam prevent nausea and vomiting during spinal anesthesia for cesarean section.
  3. 3 Prophylaxis of intra- and postoperative nausea and vomiting in patients during cesarean section in spinal anesthesia [DOI]
  4. 4 Comparison of the effect of general and spinal anesthesia for elective cesarean section on maternal and fetal outcomes: a retrospective cohort study [DOI]
  5. 5 Antiemetic effect of propofol administered at the end of surgery in laparoscopic assisted vaginal hysterectomy [DOI]
  6. 6 The Effect of Sedation Protocol Using Richmond AgitationSedation Scale (RASS) on Some Clinical Outcomes of Mechanically Ventilated Patients in Intensive Care Units: a Randomized Clinical Trial [DOI]
  7. 7 The incidence and factors associated with intraoperative nausea and vomiting during cesarean section under spinal anesthesia, July 2019. An institution based cross sectional study [DOI]
  8. 8 The effect of acupressure on nausea and vomiting after cesarean section under spinal anesthesia.
  9. 9 Midazolam as an anti-emetic.
  10. 10 Use of propofol for prevention of post-delivery nausea during cesarean section: a double-blind, randomized, placebo-controlled trial [DOI]
  11. 11 COMPARISON OF METOCLOPRAMIDE AND LOW DOSE PROPOFOL FOR PROPHYLAXIS OF NAUSEA & VOMITING AFTER CESAREAN SECTION
  12. 12 Antiemetic Effects of Midazolam and Propofol during Spinal Anesthesia on Women Undergoing Elective Cesarean Sections [DOI]

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