Effect of the Combination of Stem Bark Extract of Parkia biglobosa (Jacq) Benth and Certain Antibiotics  against Some Organisms of  Medical Importance

Darlington Ugochukwu Onele; Ememobong Gideon Asuquo; Chinweizu Ejikeme Udobi; Chibuzor Nneamaka Nwosu; Edet Effiong Akpanenang; Esther Chinonye Ugwoke

doi:10.9734/ejmp/2023/v34i101165

Research Article Open access CC BY 4.0

Effect of the Combination of Stem Bark Extract of Parkia biglobosa (Jacq) Benth and Certain Antibiotics against Some Organisms of Medical Importance

Darlington Ugochukwu Onele, Ememobong Gideon Asuquo, Chinweizu Ejikeme Udobi, Chibuzor Nneamaka Nwosu, Edet Effiong Akpanenang, Esther Chinonye Ugwoke

European Journal of Medicinal Plants · pp. 53–62 · Published 1 Dec 2023

10.9734/ejmp/2023/v34i101165

Abstract

Plant-derived compounds are known to exhibit a direct antibacterial activity and or an indirect activity as antibiotic resistance modifying compounds, and when combined with antibiotics, increased effectiveness may be observed. In this study, effort was directed towards combining the aqueous fraction of the methanol extract of the stem bark of Parkia biglobosa with some antibiotics to observe their combination effects on some organisms of medical importance. The minimum inhibitory concentration (MIC) of the extract and test antibiotics was determined using the checkerboard assay. Combination studies were carried out to ascertain the activities of the combinations against test organisms using the rate of kill assay and checkerboard assay. Results obtained confirmed interaction between the plant extract and the test antibiotics. It specifically confirmed synergistic interaction between Tetracycline, Erythromycin and Nalidixic acid respectively and the extract against Pseudomonas aeruginosa and Escherichia coli. Results obtained proved that in the search for alternative ways of combating bacterial infections, combination of plant extract with antibiotics could boost effectiveness and the aqueous fraction of the methanol extract of Parkia biglobosa is a possible candidate for this purpose against two of the tested organisms.

Stem bark extract antibacterial activity Parkia biglobosa checkerboard

References (11)

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Darlington Ugochukwu Onele, Ememobong Gideon Asuquo, Chinweizu Ejikeme Udobi, Chibuzor Nneamaka Nwosu, Edet Effiong Akpanenang, Esther Chinonye Ugwoke (2023). Effect of the Combination of Stem Bark Extract of Parkia biglobosa (Jacq) Benth and Certain Antibiotics against Some Organisms of Medical Importance. European Journal of Medicinal Plants , 53–62. https://doi.org/10.9734/ejmp/2023/v34i101165

Affiliations

Darlington Ugochukwu Onele — Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmacy, University of Uyo, Nigeria.
Ememobong Gideon Asuquo — Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmacy, University of Uyo, Nigeria.
Chinweizu Ejikeme Udobi — Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmacy, University of Uyo, Nigeria.
Chibuzor Nneamaka Nwosu — Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmacy, University of Uyo, Nigeria.
Edet Effiong Akpanenang — Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmacy, University of Uyo, Nigeria.
Esther Chinonye Ugwoke — Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmacy, University of Uyo, Nigeria.

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