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Research Article Open access CC BY 3.0

Effect of Progressive Resistance Exercise Training on Hepatic Fat in Asian Indians with Non-Alcoholic Fatty Liver Disease

Kirti Damor, Kanchan Mittal, Ashu Seith Bhalla, Rita Sood, Ravindra M. Pandey, Randeep Guleria, Kalpana Luthra, Naval K. Vikram

Journal of Advances in Medicine and Medical Research · pp. 114–124 · Published 14 Sep 2013

10.9734/BJMMR/2014/4845

Abstract

Introduction: Nonalcoholic fatty liver disease (NAFLD) is closely associated with obesity and insulin resistance and lifestyle measures form the cornerstone of therapy. Objective: To study the effect of progressive resistance training (PRT) on hepatic fat content, body composition and insulin sensitivity in patients with NAFLD. Methods: This study included 24 adult patients with NAFLD diagnosed on ultrasonography. Subjects with alcohol intake >140 gm/week and any secondary cause of fatty liver were excluded. Patients underwent thrice weekly sessions (40 minutes each) of resistance exercises including flexion at biceps, triceps, and hip flexion, knee extension and heel rise for 12 weeks. Pre- and post-intervention evaluation included anthropometry, BIA analysis, short insulin tolerance test (SITT), lipid profile and hepatic fat quantification by MRI. Results: Twenty four patients (17 males, 7 females, mean age 39.8±10.5 yrs) completed the study protocol with 78.7% compliance to PRT protocol. There was significant decrease in waist, hip and mid-thigh circumferences and skinfold thicknesses at biceps, triceps, subscapular and suprailiac regions (p<0.05), with no significant change in BMI and WHR. Insulin sensitivity improved significantly at 12 weeks as indicated by increase in k-value (rate of change of glucose) on SITT (0.84 vs 1.3, p=0.002). A decrease in total cholesterol and LDL-c with increase in HDL-c was noted after 12 weeks (p<0.05). Hepatic fat content also decreased at 12 weeks (22.3±3.9 vs 21.4±4.0 %, p=0.01). Conclusion: Moderate intensity PRT is associated with significant improvement in hepatic fat, truncal subcutaneous fat and insulin sensitivity in patients with NAFLD.

NAFLD resistance exercise insulin resistance Asian Indians.

References (34)

  1. 1 Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge [DOI]
  2. 2 The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association [DOI]
  3. 3 Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease [DOI]
  4. 4 Randomized Controlled Trial Testing the Effects of Weight Loss on Nonalcoholic Steatohepatitis [DOI]
  5. 5 AGA technical review on nonalcoholic fatty liver disease [DOI]
  6. 6 Defective Hepatic Mitochondrial Respiratory Chain in Patients With Nonalcoholic Steatohepatitis [DOI]
  7. 7 Aerobic Exercise Training Reduces Hepatic and Visceral Lipids in Obese Individuals Without Weight Loss† [DOI]
  8. 8 Therapeutic effects of restricted diet and exercise in obese patients with fatty liver [DOI]
  9. 9 The Diagnosis and Management of Non-alcoholic Fatty Liver Disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association [DOI]
  10. 10 Exercise and non-alcoholic fatty liver disease: A systematic review and meta-analysis [DOI]
  11. 11 Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: A systematic review [DOI]
  12. 12 Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss [DOI]
  13. 13 Cytokines and Nash: A Pilot Study of the Effects of Lifestyle Modification and Vitamin E [DOI]
  14. 14 Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men [DOI]
  15. 15 Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis [DOI]
  16. 16 Habitual Physical Activity Is Associated With Intrahepatic Fat Content in Humans [DOI]
  17. 17 Mitochondrial dysfunction and lipotoxicity [DOI]
  18. 18 Hepatic MRI for Fat Quantitation [DOI]
  19. 19 Benefits of lifestyle modification in NAFLD [DOI]
  20. 20 Effect of exercise and dietary modification on serum aminotransferase levels in patients with nonalcoholic steatohepatitis [DOI]
  21. 21 Effect of Supervised Progressive Resistance-Exercise Training Protocol on Insulin Sensitivity, Glycemia, Lipids, and Body Composition in Asian Indians With Type 2 Diabetes [DOI]
  22. 22 Temporal pattern of de novo lipogenesis in the postprandial state in healthy men1–3 [DOI]
  23. 23 Nonalcoholic fatty liver in Asia: Firmly entrenched and rapidly gaining ground [DOI]
  24. 24 Regular Exercise Is Associated with a Reduction in the Risk of NAFLD and Decreased Liver Enzymes in Individuals with NAFLD Independent of Obesity in Korean Adults [DOI]
  25. 25 Nonalcoholic fatty liver disease is associated with subclinical atherosclerosis independent of obesity and metabolic syndrome in Asian Indians [DOI]
  26. 26 Effect of Endurance Exercise on Hepatic Lipid Content, Enzymes, and Adiposity in Men and Women [DOI]
  27. 27 Non-alcoholic and alcoholic Fatty Liver Disease - two Diseases of Affluence associated with the Metabolic Syndrome and Type 2 Diabetes: the FIN-D2D Survey [DOI]
  28. 28 Life style modification improves insulin resistance and liver histology in patients with non-alcoholic fatty liver disease [DOI]
  29. 29 Home-Based Resistance Training Is Not Sufficient to Maintain Improved Glycemic Control Following Supervised Training in Older Individuals With Type 2 Diabetes [DOI]
  30. 30 Regulation of fat metabolism in the liver: link to non-alcoholic hepatic steatosis and impact of physical exercise [DOI]
  31. 31 Pioglitazone Decreases Fasting and Postprandial Endogenous Glucose Production in Proportion to Decrease in Hepatic Triglyceride Content [DOI]
  32. 32 Second World Congress on the Insulin Resistance Syndrome [DOI]
  33. 33 Indian patients with nonalcoholic fatty liver disease presenting with raised transaminases are different at presentation [DOI]
  34. 34 Non-alcoholic and alcoholic Fatty Liver Disease - two Diseases of Affluence associated with the Metabolic Syndrome and Type 2 Diabetes: the FIN-D2D Survey [DOI]

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