Skip to content
Research Article Open access CC BY 4.0

Effect of Ketamine Spraying on the Postoperative Sore Throat and Hoarseness after Tracheal Intubation

Vida Ayatollahi, Faride Moslemin, Shekufeh Behdad, Maryam Hatami

Journal of Advances in Medicine and Medical Research · pp. 1–7 · Published 22 Aug 2016

10.9734/BJMMR/2016/26873

Abstract

Aims: Sore throat, hoarseness, and cough are postoperative complications caused by tracheal intubation in general anesthesia. The aim of this study was to investigate the role of preoperative ketamine splashing on reducing postoperative sore throat. Study Design:  A cross-sectional/ randomized, double-blinded clinicall study. Place and Duration of Study: Departments of anesthesiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran, from Apr 2014 to Dec 2014. Methodology: This study was performed on 68 patients who were randomly assigned into two groups. The control group received 2 cc normal saline and the case group received 25 mg ketamine in 2 cc normal saline. To evaluate ketamine preoperative splashing efficacy, the incidence and severity of postoperative sore throat (post) and other complications caused by tracheal intubation were compared between two groups. Results: In the ketamine group, the incidence and severity of post were less compared to the control group. The findings revealed significant differences in terms of sore throat (in recovery time; 6 h and 12 h after surgery) and hoarseness (in recovery time) among the two groups. The investigation of patient’s vital signs showed a significant difference between groups regarding HR at 5th and 15th minutes of surgery among the two groups. No hallucination was found in either group. Conclusion: According to these results, ketamine preoperative splashing can significantly reduce the incidence and severity of postoperative complications of endotracheal intubation such as sore throat, with no side effect.

General anesthesia ketamine tracheal intubation intubation sore throat tracheal

References (24)

  1. 1 Which Clinical Anesthesia Outcomes Are Important to Avoid? The Perspective of Patients [DOI]
  2. 2 Ketamine and postoperative pain – a quantitative systematic review of randomised trials [DOI]
  3. 3 Postoperative sore throat: cause, prevention and treatment [DOI]
  4. 4 Ketamine gargle for attenuating postoperative sore throat [DOI]
  5. 5 Inflammation-induced changes in peripheral glutamate receptor populations [DOI]
  6. 6 Low dose ketamine: a therapeutic and research tool to explore N-methyl-D-aspartate (NMDA) receptor-mediated plasticity in pain pathways [DOI]
  7. 7 Effects of nebulized ketamine on allergen-induced airway hyperresponsiveness and inflammation in actively sensitized Brown-Norway rats [DOI]
  8. 8 Quality improvement in anesthetic practice--incidence of sore throat after using small tracheal tube.
  9. 9 Gargling with ketamine attenuates the postoperative sore throat.
  10. 10 Magnesium and Ketamine Gargle and Postoperative Sore Throat [DOI]
  11. 11 Benzydamine Hydrochloride (Tantum) in the management of oral inflammatory conditions.
  12. 12 Tracheal intubation and sore throat: a mechanical explanation [DOI]
  13. 13 Ketamine attenuates sepsis-induced acute lung injury via regulation of HMGB1-RAGE pathways [DOI]
  14. 14 Ketamine reduces mortality of severely burnt rats, when compared to midazolam plus fentanyl [DOI]
  15. 15 Comparison between betamethasone gel applied over endotracheal tube and ketamine gargle for attenuating postoperative sore throat, cough and hoarseness of voice.
  16. 16 Evidence for the interaction of glutamate and NK1 receptors in the periphery [DOI]
  17. 17 Intraplantar injection of dextrorphan, ketamine or memantine attenuates formalin-induced behaviors [DOI]
  18. 18 Ketamine gargling and postoperative sore throat [DOI]
  19. 19 Postoperative sore throat: incidence and severity after the use of lidocaine, saline, or air to inflate the endotracheal tube cuff.
  20. 20 Ketamine/Xylazine attenuates LPS-induced iNOS expression in various rat tissues [DOI]
  21. 21 The effect of intravenous low dose ketamine for reducing postoperative sore throat [DOI]
  22. 22 Postoperative sore throat: incidence, risk factors, and outcome.
  23. 23 Topical and Peripheral Ketamine as an Analgesic [DOI]
  24. 24 The efficacy of ketamine gargles on postoperative sore throat

Cited by 2

Topical application of ketamine to prevent postoperative sore throat in adults: A systematic review and meta‐analysis

Akira Kuriyama, Misuzu Nakanishi, Jun Kamei · Acta Anaesthesiologica Scandinavica · 2020

Showing 1 of 2 known citations — external sources report more than can currently be individually listed.

Related research

Article metrics

Real usage data collected on this platform.

77

Page views

0

PDF downloads

26

Outbound clicks

2

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.