Study of the Potential Role of Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) Levels in the Diagnosis and Prognosis of Breast Cancer in Egyptian Females "A Case-Control Study"
F. Z. Mohammed, Lamis Gamal, Mohamed Farouk Mosa, I. M. El- deen
Asian Journal of Research in Biochemistry · pp. 1–8 · Published 18 Jul 2020
10.9734/ajrb/2020/v7i130128Abstract
Background: Breast cancer (BC) is the most common cause of malignancy in females all over the world. Continuous scientific research for the discovery of new markers helping is a cornerstone for early disease detection and proper management. Aim of the Study: This study aimed to evaluate the role of Neutrophil gelatinase-associated lipocalin (NGAL) as prognostic markers for breast cancer in an Egyptian female population. Patients and Methods: 120 BC patients and 30 healthy controls were the subjects of the study; serum NGAL levels were investigated and correlated with the clinicopathologic characteristics of the BC patients. Results: Our study showed that NGAL was significantly different between healthy controls and BC patients, and it revealed a gradual increase with disease severity. Conclusion: Our findings suggested that NGAL could be diagnostic marker for early case detection, and was shown to be associated with breast cancer prognosis, supporting its role as prognostic biomarker.
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Al-Shimaa Mahmoud Abas, Mohamed H. Sherif, Sara A. Elmoneam Farag · International Journal of Breast Cancer · 2022
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