Mild Hyperoxia Stimulation Increases Regional Tissue Oxygen Pressure in Rat Hippocampus via Oxygen Radical
H. Yoshizato, Osung Kwon, S. Ato, R. Ogasawara, Y. Hanai, Y. Yoshimura
Journal of Applied Life Sciences International · pp. 1–8 · Published 21 Aug 2019
10.9734/jalsi/2019/v21i430113Abstract
Aims: The purpose of this study is to examine a rise of the local tissue oxygen pressure in hippocampus (Hip-pO2) which means neuronal activation by mild hyperoxia through oxygen radical. Study Design: Study was an animal experiment with rat. Place and Duration of Study: Department of Department of Life Science and Applied Chemistry, Nagaya Institute of Technology, between January 2014 and January 2018. Methodology: Rats were exposed to air or mild oxygen gas. At the same time, Local tissue oxygen pressure in hippocampus (Hip-pO2) were measured for 20 min with or without treatment of two type of radical scavengers. Results: The Hip-pO2 levels were significantly increased by mild hyperoxia exposure (50-60% above resting level). The mild hyperoxia-induced enhancement of the Hip-pO2 levels were inhibited by MnTMPyP (radical scavenger), but not by NADPH oxidase (NOX) inhibitor Apocynin. Conclusion: These findings suggested that mild hyperoxia could activate hippocampus through generation of oxygen radicals.
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