Component-resolved Diagnostics in Latex Allergy: Molecular Insights from Three Clinical Cases

Abstract

Background: Natural rubber latex allergy is an important cause of occupational and healthcare-related hypersensitivity. Cross-reactivity with plant-derived foods is frequent and complicates diagnosis. Case Presentation: We report three women with suspected latex allergy investigated using component-resolved diagnostics (CRD) by the ALEX biochip. - Case 1: A 33-year-old nurse with recurrent eczematous lesions triggered by medical gloves was sensitized to Hev b 5 (17.3 kUA/L) and Der p 23 (0.5 kUA/L), despite negative skin testing. - Case 2: A 32-year-old office worker with urticaria, angioedema, and dyspnea showed polysensitization to multiple house dust mite allergens (Der f 1, Der f 2, Der p 1, Der p 2, Der p 23), Fel d 1, and kiwi allergens (Act d 2, Act d 5), in addition to Hev b 11, consistent with latex–fruit syndrome. - Case 3: A 40-year-old physician with contact eczema was monosensitized to Hev b 11. Conclusion: CRD provided key insights into differentiating primary latex sensitization from cross-reactivity. This approach refines diagnosis and supports personalized management of latex allergy.