Probiotics as a Therapeutic Approach in Treatment of Inflammatory Bowel Disease

Abstract

Inflammatory bowel disease is an immune mediated chronic inflammatory disorder, wherein including Ulcerative colitis, Crohn disease these are two major phenotypes of Inflammatory Bowel Disease. Even though the mechanism of Inflammatory disease is still unclear, probiotic strains have found to have a potential effect in management of the disease. Until now, remarkable advancement has been elucidated in the treatment, however, numerous alternative choices are persistently hunted that might prevent remission of disease. Probiotics are described as living organisms that act as a driving force, wherein exerting health benefits beyond primary nourishment. In view of clinical perspective the efficacy of probiotics seems to be absolutely robust in terms of experimental analysis. Moreover, there is a substantial rise in evidence that probiotics may likely modify the disease manifestations including animal models and in those suffering from Inflammatory Bowel Disease. Considerably, the effect might occur due to divergence in concentration of micro organism used and the vulnerability of the progression of disease is managed .In striking contrast, due to ambiguous research in sequencing technology has conditionally led to the recognition of gut microbiota framework of IBD. Numerous clinical trials depicted the use of probiotics, dysbiosis, microbiota as promising therapies in Inflammatory Bowel Disease. This review elucidates about the role of probiotics, its beneficial effects, summary of literature review in treatment of Inflammatory bowel disease.