Study on the Anti-inflammatory and Anti-nociceptive Activities of Methanol Extracts of Terminalia ivorensis A. Chev

Abstract

Aims: The present study was aimed at the determination of the anti-inflammatory and anti-nociceptive potentials of methanolic extracts of the stem and root bark of Terminalia ivorensis A. Chev (Combretaceae). Study Design: The study design involved isolation of crude extracts from T. ivorensis and evaluation of the anti-inflammatory and anti-nociceptive potentials. Place and Duration of Study: T. Ivoriensis Stem Bark (TISB) and Root Bark (TIRB) were collected from a location in Ore, Ondo State, Nigeria, in January 2017. Methodology: Plant samples were extracted with 90% methanol using Soxhlet extractor. Egg-albumin induced inflammation and hot plate tests were used to evaluate the anti-inflammatory and anti-nociceptive activity respectively at a dose of 100, 200 and 400 mg/kg. Results: Extract yield of the TIRB and TISB were 20% and 24% respectively. Both extracts displayed high anti-nociceptive activities (at the peak of p<0.001) relative to time and concentration except the 400 mg/kg of TISB with reduced activity (p<0.01 at the 4th h). The egg-albumin induced inflammation was inhibited by the extracts in different doses. TISB displayed non-significant inhibition properties for all the doses. However, the 100 mg/kg of root bark showed a p<0.05 activity minimal at the 30th and 60th min but declined to non-significance as the reaction proceeds. The dose of 400 mg/kg showed a steep rise in activity from p<0.05 to p<0.01 at the 3rd and 4th h. Conclusion: This study has shown that TISB and TIRB possess both anti-nociceptive and anti-inflammatory properties and thus the plant can be exploited for such.