Distribution and Implications of Mycobacterium Tuberculosis Genotypes in Animals: A Comprehensive Review

Abstract

This narrative review discusses the spread of Mycobacterium tuberculosis among animal populations, focusing on M. tuberculosis genotype distribution and frequency across different species. To develop comprehensive tuberculosis control strategies under the One Health approach, it is important to have an understanding of the genotypes of M. tuberculosis in animals. Animal infections are discussed, as well as the pathogenesis and epidemiology of M. tuberculosis. Various genotyping methods, including spoligotyping, MIRU-VNTR, and whole genome sequencing, are discussed in the review, emphasizing their role in understanding strain diversity and transmission dynamics. There are many factors influencing the distribution of M. tuberculosis genotypes in animals, including environmental conditions, host factors, human-animal interactions, and animal trade practices. It is clear from the review that the Euro-American lineage is widely distributed across animal species, with the Beijing genotype becoming increasingly prevalent in regions where it is prevalent in humans. The study highlights the need for more comprehensive genotyping studies as well as the development of better diagnostic tools. This will enhance our understanding of M. tuberculosis in animal populations. A conclusion to the review, emphasizes that standardizing genotyping protocols, utilizing whole genome sequencing, and fostering international collaboration are essential for improving our understanding of M. tuberculosis diversity in animals and developing targeted tuberculosis control strategies. The impact of Mycobacterium tuberculosis genotypes in animals is multi-faceted, affecting both public health and veterinary practices. Addressing these challenges requires a coordinated and comprehensive approach that considers the interconnectedness of human and animal health systems, fosters research, enhances surveillance, and implements effective control strategies.