Discriminating Benign and Malignant Brain Tumors By Spectral Analysis of Cerebrospinal Fluid

V. Masilamani; R. Vidhya Shree; Ajay T. Prasad; Kannan Ramamurthy; Chellappan Selvaraju; Wafa Mohammed Alsaleh; Tahani A. Alrebdi; Trinka Vijmasi; A. Thiruvalluvan; V. Chandramouleeswaran

doi:10.9734/jpri/2022/v34i49A36425

Research Article Open access CC BY 4.0

Discriminating Benign and Malignant Brain Tumors By Spectral Analysis of Cerebrospinal Fluid

V. Masilamani, R. Vidhya Shree, Ajay T. Prasad, Kannan Ramamurthy, Chellappan Selvaraju, Wafa Mohammed Alsaleh, Tahani A. Alrebdi, Trinka Vijmasi, A. Thiruvalluvan, V. Chandramouleeswaran

Journal of Pharmaceutical Research International · pp. 37–48 · Published 2 Sep 2022

10.9734/jpri/2022/v34i49A36425

Abstract

The preliminary study is concerned with an innovative technique for the discrimination of malignant brain tumor from benign with reasonable sensitivity and specificity. The entire study is based on the relative fluorescence intensity and life-time of bio-fluorophores like tryptophan and tyrosine which are then validated as a set of ratio parameters. Resultantly, it was seen that malignancy was characterized by three-fold enhancement of tyrosine. The picosecond-time resolved decay time measurement was done, which exhibited two-fold decrease in decay time for malignant sample. The improved accessibility, with minimal invasiveness to the patient, and lower cost are encouraging aspects of this technique.

Cerebrospinal fluid (CSF) fluorescence spectra time resolved spectra malignant brain tumor benign brain tumor

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V. Masilamani, R. Vidhya Shree, Ajay T. Prasad, Kannan Ramamurthy, Chellappan Selvaraju, Wafa Mohammed Alsaleh, Tahani A. Alrebdi, Trinka Vijmasi, A. Thiruvalluvan, V. Chandramouleeswaran (2022). Discriminating Benign and Malignant Brain Tumors By Spectral Analysis of Cerebrospinal Fluid. Journal of Pharmaceutical Research International , 37–48. https://doi.org/10.9734/jpri/2022/v34i49A36425

Affiliations

V. Masilamani — Masila Research Centre, Thiruppangili-620015, India.
R. Vidhya Shree — Sri Venkateswara Engineering College, Sriperumbudur-602117, India.
Ajay T. Prasad — Department of Neurosurgery, Madras Medical College, Chennai-600002, India.
Kannan Ramamurthy — National Centre for Ultrafast Processes, University of Madras, Chennai-600113, Tamil Nadu, India.
Chellappan Selvaraju — National Centre for Ultrafast Processes, University of Madras, Chennai-600113, Tamil Nadu, India.
Wafa Mohammed Alsaleh — College of Science and Health Professions, King Saud bin Abdulaziz University for Health Science, Saudi Arabia and Department of Physics, College of Science, Hofuf, Saudi Arabia.
Tahani A. Alrebdi — Department of Physics, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box-84428, Riyadh 11671, Saudi Arabia.
Trinka Vijmasi — Masila Research Centre, Thiruppangili-620015, India.
A. Thiruvalluvan — Department of Neurosurgery, Madras Medical College, Chennai-600002, India.
V. Chandramouleeswaran — Department of Neurosurgery, Madras Medical College, Chennai-600002, India.

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