Computational Analysis of Genomic Regions of Human Insulin Receptor Gene

Abstract

Insulin plays an essential role in metabolic control of multiple cellular processes. A number of DNA sequences that regulate transcription of the insulin gene have already been identified. The regulation of carbohydrates and fats can be operated by insulin specific receptor molecules. Previously, insulin was found to be a polypeptide in 1928 with its amino acid sequence identified in 1952. In fact it was considered as a dipeptide, containing A and B chains respectively, linked by disulphide bridges. The insulin receptor plays a critical role both in directing insulin to specific target tissues and in initiating the response of these tissues to the hormone. Hence, the study was performed to analyze the insulin gene receptor associated with regulation of various mechanism and also with several insulin deficiency syndromes. Identification of protein domains from PROSITE, Pfam and UniPROt reveals various conserved regions associated with insulin receptor gene (INSR). For this, various bioinformatics tools and software’s were used.