Design, Synthesis of Mannich Bases Derivatives of Thiosemicarbazide and their Evaluation for Anticancer Activity using Potato Disk Bioassay Method
Geetanjali Sandip Patil, Sachin Ashok Pishawikar
Journal of Pharmaceutical Research International · pp. 53–62 · Published 26 Mar 2022
10.9734/jpri/2022/v34i27B36007Abstract
Mannich bases and thiosemicarbazide individually are known to show verity of pharmacological activities such as anti-inflammatory, anticancer, antifilarial, antibacterial, antifungal, anticonvulsant, anthelmintic, antitubercular, analgesic, anti-HIV, antimalarial, antipsychotic, antiviral and so forth. As novel attempt in present work in first step synthesis of verity of mannich bases is done using structurally different types of aldehyde, ketones and amines. The condensation of synthesized mannich bases is done with thiosemicarbazide to form a novel class of compounds called mannich bases of thiosemicarbazide. Use of bioassay is one of the ways of carrying out preliminary investigation of activity. A. tumefaciens induced potato disc tumor assay has been used to investigate anticancer activity of synthesized compounds. The compounds B2, B4, B25, B26, B28, B29 and B30 have shown same or better inhibitory activity compared to Gemcitabine used as standard.
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