Comparison on Safety and Efficacy of Telmisartan and Losartan with their Effects on Cardiovascular – A Single Centre Study

Abstract

Two of the major determinants of cardiovascular disease, hypertension and hyperlipidemia, commonly coexist. There is high prevalence (5 -25%) of low high  density lipoprotein (HDL) cholesterol and a higher  prevalence of elevated Triglyceride (TGL) levels in hypertensive compared to normotensive  individuals. Elevated total cholesterol (TC) levels augment the risk of cardiovascular disease associated with hypertension. This study aimed to determine the antihypertensive & pleiotropic effects of telmisartan and losartan in patients with mild to moderate hypertension. All the subjects were between the ages of 18 -65 years. 100 subjects were selected for the study and their serum total cholesterol, HDL, LDL, VLDL, Triglyceride, Systolic blood pressure, diastolic blood pressure, heart rate were analyzed at  the beginning of the study and 12th  and  24 the week. Adverse events are also noted in each visit. All data entered in SPSS 10 version and scores obtained were statistically evaluated using student t test, chi square test and ANOVA. The study showed both telmisartan and losartan good control over hypertension in patients. Telmisartan has pleiotropic positive effect on lipid profile.